CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045005
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Putative oxidoreductase GLYR1 
Protein Synonyms/Alias
  
Gene Name
 GLYR1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
123KLSLSEGKVKKNMGEacetylation[1, 2]
199PTASEPVKDADPHFHubiquitination[3]
273VWNRTAEKCDLFIQEubiquitination[2, 4]
309VSDPKAAKDLVLGPSubiquitination[2, 3, 4]
466NILQGNFKPDFYLKYubiquitination[2, 3, 4, 5]
476FYLKYIQKDLRLAIAubiquitination[2, 4]
503AAANEVYKRAKALDQubiquitination[2, 4]
506NEVYKRAKALDQSDNubiquitination[2, 3, 4, 5, 6, 7]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 524 AA 
Protein Sequence
XGKLGRYPPW PGKIVNPPKD LKKPRGKKCF FVKFFGTEDH AWIKVEQLKP YHAHKEEMIK 60
INKGKRFQQA VDAVEEFLRR AKGKDQTSSH NSSDDKNRRN SSEERSRPNS GDEKRKLSLS 120
EGKVKKNMGE GKKRVSSGSS ERGSKSPLKR AQEQSPRKRG RPPKDEKDLT IPESSTVKGM 180
MAGPMAAFKW QPTASEPVKD ADPHFHHFLL SQTEKETGST SIQAADSTAV NGSITPTDKK 240
IGFLGLGLMG SGIVSNLLKM GHTVTVWNRT AEKCDLFIQE GARLGRTPAE VVSTCDITFA 300
CVSDPKAAKD LVLGPSGVLQ GIRPGKCYVD MSTVDADTVT ELAQVIVSRG GRFLEAPVSG 360
NQQLSNDGML VILAAGDRGL YEDCSSCFQA MGKTSFFLGE VGNAAKMMLI VNMVQGSFMA 420
TIAEGLTLAH VTGQSQQTLL DILNQGQLAS IFLDQKCQNI LQGNFKPDFY LKYIQKDLRL 480
AIALGDAVNH PTPMAAAANE VYKRAKALDQ SDNDMSAVYR AYIH 524 
Gene Ontology
 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
 GO:0006098; P:pentose-phosphate shunt; IEA:InterPro. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR006115; 6PGDH_NADP-bd.
 IPR017956; AT_hook_DNA-bd_motif.
 IPR013328; DH_multihelical.
 IPR015815; HIBADH-type.
 IPR016040; NAD(P)-bd_dom.
 IPR000313; PWWP. 
Pfam
 PF03446; NAD_binding_2
 PF00855; PWWP 
SMART
 SM00384; AT_hook 
PROSITE
 PS50812; PWWP 
PRINTS