| Tag | Content |
|---|
| CPLM ID | CPLM-016998 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Centrosomal protein of 97 kDa |
Protein Synonyms/Alias | Cep97; Leucine-rich repeat and IQ domain-containing protein 2 |
Gene Name | CEP97 |
Gene Synonyms/Alias | LRRIQ2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 241 | DGYVISQKESLKAEW | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome. |
Sequence Annotation | REPEAT 37 58 LRR 1.
REPEAT 59 80 LRR 2.
REPEAT 81 102 LRR 3.
REPEAT 103 124 LRR 4.
REPEAT 125 146 LRR 5.
REPEAT 147 168 LRR 6.
REPEAT 171 192 LRR 7.
REPEAT 196 205 LRR 8.
DOMAIN 211 249 LRRCT.
DOMAIN 558 587 IQ.
REGION 300 750 CCP110-binding.
MOD_RES 308 308 Phosphoserine.
MOD_RES 314 314 Phosphoserine.
MOD_RES 413 413 Phosphoserine.
MOD_RES 763 763 Phosphoserine. |
Keyword | Alternative splicing; Calmodulin-binding; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Leucine-rich repeat; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 865 AA |
Protein Sequence | MAVARVDAAL PPGEGSVVNW SGQGLQKLGP NLPCEADIHT LILDKNQIIK LENLEKCKRL 60
IQLSVANNRL VRMMGVAKLT LLRVLNLPHN SIGCVEGLKE LVHLEWLNLA GNNLKAMEQI 120
NSCTALQHLD LSDNNISQIG DLSKLVSLKT LLLHGNIITS LRMAPAYLPR SLAILSLAEN 180
EIRDLNEISF LASLTELEQL SIMNNPCVMA TPSIPGFDYR PYIVSWCLNL RVLDGYVISQ 240
KESLKAEWLY SQGKGRAYRP GQHIQLVQYL ATVCPLTSTL GLQTAEDAKL EKILSKQRFH 300
QRQLMNQSQN EELSPLVPVE TRASLIPEHS SPVQDCQISQ ESEPVIQVNS WVGINSNDDQ 360
LFAVKNNFPA SVHTTRYSRN DLHLEDIQTD EDKLNCSLLS SESTFMPVAS GLSPLSPTVE 420
LRLQGINLGL EDDGVADESV KGLESQVLDK EEEQPLWAAN ENSVQMMRSE INTEVNEKAG 480
LLPCPEPTII SAILKDDNHS LTFFPESTEQ KQSDIKKPEN TQPENKETIS QATSEKLPMI 540
LTQRSVALGQ DKVALQKLND AATKLQACWR GFYARNYNPQ AKDVRYEIRL RRMQEHIVCL 600
TDEIRRLRKE RDEERIKKFV QEEAFRFLWN QVRSLQVWQQ TVDQRLSSWH TDVPPISSTL 660
VPSKHPLFTQ SQESSCDQNA DWFIASDVAP QEKSLPEFPD SGFHSSLTEQ VHSLQHSLDF 720
EKSSTEGSES SIMGNSIDTV RYGKESDLGD VSEEHGEWNK ESSNNEQDNS LLEQYLTSVQ 780
QLEDADERTN FDTETRDSKL HIACFPVQLD TLSDGASVDE SHGISPPLQG EISQTQENSK 840
LNAEVQGQQP ECDSTFQLLH VGVTV 865 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |