UniProt Accession

 VTI1B_HUMAN; Q9UEU0; O43547; Q96J28 

Genbank Protein ID

 AF035824; AF060902; CR456757; CR542095; BT019348; BC003142 

Genbank Nucleotide ID

 AAC52016.1; AAC73059.1; CAG33038.1; CAG46892.1; AAV38155.1; AAH03142.1 

Protein Name

 Vesicle transport through interaction with t-SNAREs homolog 1B 

Protein Synonyms/Alias

 Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1 

Gene Name

 VTI1B 

Gene Synonyms/Alias

 VTI1; VTI1L; VTI1L1; VTI2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	ASSEHFEKLHEIFRG	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Endosome; Lysosome; Membrane; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 232 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; IDA:UniProtKB.
 GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0031201; C:SNARE complex; IEA:Compara.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0006944; P:cellular membrane fusion; TAS:ProtInc.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0006904; P:vesicle docking involved in exocytosis; TAS:ProtInc. 

Interpro

 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom.
 IPR007705; Vesicle_trsprt_v-SNARE_N. 

Pfam

 PF05008; V-SNARE 

SMART

 SM00397; t_SNARE 

PROSITE

  

PRINTS