CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015881
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family F member 1 
Protein Synonyms/Alias
 ATP-binding cassette 50 
Gene Name
 ABCF1 
Gene Synonyms/Alias
 ABC50 
Created Date
 July 27, 2013 
Organism
 Pan troglodytes (Chimpanzee) 
NCBI Taxa ID
 9598 
Lysine Modification
Position
Peptide
Type
References
39KKDKKIKKTFFEELAubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity). 
Sequence Annotation
 DOMAIN 266 510 ABC transporter 1.
 DOMAIN 587 802 ABC transporter 2.
 NP_BIND 298 305 ATP 1 (By similarity).
 NP_BIND 620 627 ATP 2 (By similarity).
 MOD_RES 22 22 Phosphoserine (By similarity).
 MOD_RES 24 24 Phosphoserine (By similarity).
 MOD_RES 105 105 Phosphoserine (By similarity).
 MOD_RES 109 109 Phosphoserine; by CK2 (By similarity).
 MOD_RES 140 140 Phosphoserine; by CK2 (By similarity).
 MOD_RES 166 166 Phosphoserine (By similarity).
 MOD_RES 557 557 Phosphoserine (By similarity).
 CROSSLNK 535 535 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 544 544 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Activator; ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 807 AA 
Protein Sequence
MPKAPKQQPP EPEWIGDGES TSPSDKVVKK GKKDKKIKKT FFEELAVEDK QAGEEEKVLK 60
EKEQQQQQQQ VQQKKKRDTR KGRRKKDVDD DGEEKELMER LKKLSVPASD EEDEVPAPKP 120
RGGKKTKGGN VFAALIQDQS EEEEEEEKHP PKPAKPEKNR INKAVSEEQQ PALKGKKGKE 180
EKSKGKAKPQ NKFAALDNEE EDKEEEIIKE KEPPKQGKEK AKKAEQMEYE RQVASLKAAN 240
AAENDFSVSQ AEMSSRQAML ENASDIKLEK FSISAHGKEL FVNADLYIVA SRRYGLVGPN 300
GKGKTTLLKH IANRALSIPP NIDVLLCEQE VVADETPAVQ AVLRADTKRL KLLEEERRLQ 360
GQLEQGDDTA AERLEKVYEE LRATGAAAAE AKARRILAGL GFDPEMQNRP TQKFSGGWRM 420
RVSLARALFM EPTLLMLDEP TNHLDLNAVI WLNNYLQGWR KTLLIVSHDQ GFLDDVCTDI 480
IHLDAQRLHY YRGNYMTFKK MYQQKQKELL KQYEKQEKKL KELKAGGKST KQAEKQTKEA 540
LTRKQQKCRR KNQDEESQEA PELLKRPKEY TVRFTFPDPP PLSPPVLGLH GVTFGYEGQK 600
PLFKNLDFGI DMDSRICIVG PNGVGKSTLL LLLTGKLTPT HGEMRKNHRL KIGFFNQQYA 660
EQLRMEETPT EYLQRGFNLP YQDARKCLGR FGLESHAHTI QICKLSGGQK ARVVFAELAC 720
REPDVLILDE PTNNLDIESI DALGEAINEY KGAVIVVSHD ARLITETNCQ LWVVEEQSVS 780
QIDGDFEDYK REVLEALGEV MVSRPRE 807 
Gene Ontology
 GO:0005635; C:nuclear envelope; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; ISS:UniProtKB.
 GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0043022; F:ribosome binding; ISS:UniProtKB.
 GO:0008494; F:translation activator activity; ISS:UniProtKB.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006413; P:translational initiation; ISS:UniProtKB. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS