UniProt Accession

 H2A_CAEEL; P09588; Q7JKF5 

Genbank Protein ID

 X15633; FO081169; FO081135; FO081551; FO081551; FO081223; Z73102; Z81128; Z81495; Z82271; Z83245; Z83245; Z92789; Z93388; FO081059; FO081059; FO081018 

Genbank Nucleotide ID

 CAA33641.1; CCD69634.1; CCD69397.1; CCD72371.1; CCD72361.1; CCD70021.1; CAA97414.1; CAB03399.1; CAB04056.1; CAB05212.1; CAB05836.1; CAB05838.1; CAB07221.1; CAB07656.1; CCD68872.1; CCD68866.1; CCD68534.1 

Protein Name

 Histone H2A 

Protein Synonyms/Alias

  

Gene Name

 his-3; his-7; his-12; his-16; his-19; his-21; his-30; his-33; his-43; his-47; his-51; his-53; his-57; his-61; his-65; his-68 

Gene Synonyms/Alias

 T10C6.12; F45F2.4; ZK131.6; ZK131.10; K06C4.11; K06C4.3; F35H10.1; F17E9.13; F08G2.2; B0035.7; F07B7.10; F07B7.3; F54E12.5; F55G1.10; H02I12.7; T23D8.6 

Created Date

 July 27, 2013 

Organism

 Caenorhabditis elegans 

NCBI Taxa ID

 6239 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKGGKAKTG	acetylation	[1]
9	SGRGKGGKAKTGGKA	acetylation	[1]
11	RGKGGKAKTGGKAKS	acetylation	[1]

Reference

 [1] The primary structure of histone H2A from the nematode Caenorhabditis elegans.
 Vanfleteren JR, Van Bun SM, Van Beeumen JJ.
 Biochem J. 1987 Apr 1;243(1):297-300. [PMID: 3606579] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (Probable).
 MOD_RES 2 2 Phosphoserine (Probable).
 MOD_RES 6 6 N6-acetyllysine; partial.
 MOD_RES 9 9 N6-acetyllysine; partial.
 MOD_RES 11 11 N6-acetyllysine; partial.
 CROSSLNK 121 121 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 127 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; NAS:UniProtKB.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.