| Tag | Content |
|---|
| CPLM ID | CPLM-016757 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein SCAI |
Protein Synonyms/Alias | Suppressor of cancer cell invasion protein |
Gene Name | Scai |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 68 | DFCYLLDKSKQLFNG | ubiquitination | [1] | | 103 | DVYTKLWKFQQQHRQ | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. |
Sequence Annotation | REGION 1 212 Necessary to inhibit MKL1-induced SRF
REGION 71 173 Required for interaction with MKL1.
MOD_RES 64 64 Phosphotyrosine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repressor; Signal transduction inhibitor; Transcription; Transcription regulation; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 606 AA |
Protein Sequence | MVRGARQSQQ PRSRLAPRLS GTVEKPPRKR KSRTEFTLKE TMSSGGAEDD IPQGERKTVT 60
DFCYLLDKSK QLFNGLRDLP QYGQKQWQSY FGRTFDVYTK LWKFQQQHRQ VLDNRYGLKR 120
WQIGEIASKI GQLYYHYYLR TSETSYLNEA FSFYSAIRQR SYYSQVNKED RPELVVKKLR 180
YYARFIVVCL LLNKMDVVKD LVKELSDEIE DYTHRFNTED QVEWNLVLQE VAAFIEADPV 240
MVLNDDNTIV ITSNRLAETG APLLEQGMIV GQLSLADALI IGNCNNQVKF SELTVDMFRM 300
LQALEREPMN LASQMNKPGI QEPADKPTRR ENPHKYLLYK PTFSQLYTFL AASFKELPAN 360
SVLLIYLSAT GVFPTGRSDG EGPYDFGGVL TNSNRDIING DAIHKRNQSH KEMHCLHPGD 420
LYPFTRKPLF IVVDSSNSVA YKNFTNLFGQ PLVCLLSPTA YPKALQDQSQ RGSLFTLFLN 480
NPLMAFLFVS GLSSMRRGLW EKCQEYLRKI NRDIAQLLTH SRSIDQAFLQ FFGDEFLRLL 540
LTRFVFCSAT MRMHKAFRET RNYPESYPQL PRDETVENPH LQKHILELAS ILDVRNIFFE 600
NSMDDY 606 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0003714; F:transcription corepressor activity; IDA:UniProtKB. GO:0030336; P:negative regulation of cell migration; IGI:UniProtKB. GO:0035024; P:negative regulation of Rho protein signal transduction; IDA:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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Pfam | |
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PRINTS | |