UniProt Accession

 PPTC7_HUMAN; Q8NI37; B3KWC5; Q68DZ7; Q6UY82 

Genbank Protein ID

 AF385435; AY357944; AK124744; CH471054; BC111551; CR749216 

Genbank Nucleotide ID

 AAM43836.1; AAQ57274.1; BAG54087.1; EAW97928.1; AAI11552.1; CAH18073.1 

Protein Name

 Protein phosphatase PTC7 homolog 

Protein Synonyms/Alias

 T-cell activation protein phosphatase 2C; TA-PP2C; T-cell activation protein phosphatase 2C-like 

Gene Name

 PPTC7 

Gene Synonyms/Alias

 TAPP2C 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	FRKGLLKKGACYGDD	ubiquitination	[1]
242	LQELKKLKNSNYESI	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 DOMAIN 38 297 PP2C-like.
 METAL 78 78 Manganese 1 (By similarity).
 METAL 78 78 Manganese 2 (By similarity).
 METAL 79 79 Manganese 1; via carbonyl oxygen (By
 METAL 223 223 Manganese 2 (By similarity).  

Keyword

 Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 304 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC. 

Interpro

 IPR001932; PP2C-like. 

Pfam

 PF07228; SpoIIE 

SMART

 SM00331; PP2C_SIG
 SM00332; PP2Cc 

PROSITE

  

PRINTS