UniProt Accession

 MSI1H_HUMAN; O43347; Q96PU0; Q96PU1; Q96PU2; Q96PU3 

Genbank Protein ID

 AB012851; AC003982; AB072590; AB072591; AB072592; AB073212 

Genbank Nucleotide ID

 BAA33962.1; AAB95636.1; BAB69767.1; BAB69768.1; BAB69769.1; BAB70469.1 

Protein Name

 RNA-binding protein Musashi homolog 1 

Protein Synonyms/Alias

 Musashi-1 

Gene Name

 MSI1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
76	MDQAGVDKVLAQSRH	ubiquitination	[1]
144	DAMLMFDKTTNRHRG	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). 

Sequence Annotation

 DOMAIN 20 110 RRM 1.
 DOMAIN 109 186 RRM 2.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 191 191 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005844; C:polysome; IEA:Compara.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0008266; F:poly(U) RNA binding; IEA:Compara.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0030855; P:epithelial cell differentiation; IEA:Compara.
 GO:0007399; P:nervous system development; TAS:ProtInc.
 GO:0009725; P:response to hormone stimulus; IEA:Compara. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS