CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021510
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metal transporter CNNM2 
Protein Synonyms/Alias
 Ancient conserved domain-containing protein 2; Cyclin-M2 
Gene Name
 CNNM2 
Gene Synonyms/Alias
 ACDP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
413GTVYNREKLLEMLRVubiquitination[1]
540AMLEEFKKEHTNKKPmethylation[2]
545FKKEHTNKKPKSYQHmethylation[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). 
Sequence Annotation
 DOMAIN 258 430 DUF21.
 DOMAIN 450 511 CBS 1.
 DOMAIN 518 584 CBS 2.
 CARBOHYD 112 112 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; CBS domain; Cell membrane; Complete proteome; Disease mutation; Glycoprotein; Ion transport; Membrane; Polymorphism; Primary hypomagnesemia; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 875 AA 
Protein Sequence
MIGCGACEPK VKMAGGQAAA ALPTWKMAAR RSLSARGRGI LQAAAGRLLP LLLLSCCCGA 60
GGCAAVGENE ETVIIGLRLE DTNDVSFMEG GALRVSERTR VKLRVYGQNI NNETWSRIAF 120
TEHERRRHSP GERGLGGPAP PEPDSGPQRC GIRTSDIIIL PHIILNRRTS GIIEIEIKPL 180
RKMEKSKSYY LCTSLSTPAL GAGGSGSTGG AVGGKGGSGV AGLPPPPWAE TTWIYHDGED 240
TKMIVGEEKK FLLPFWLQVI FISLLLCLSG MFSGLNLGLM ALDPMELRIV QNCGTEKEKN 300
YAKRIEPVRR QGNYLLCSLL LGNVLVNTTL TILLDDIAGS GLVAVVVSTI GIVIFGEIVP 360
QAICSRHGLA VGANTIFLTK FFMMMTFPAS YPVSKLLDCV LGQEIGTVYN REKLLEMLRV 420
TDPYNDLVKE ELNIIQGALE LRTKTVEDVM TPLRDCFMIT GEAILDFNTM SEIMESGYTR 480
IPVFEGERSN IVDLLFVKDL AFVDPDDCTP LKTITKFYNH PLHFVFNDTK LDAMLEEFKK 540
EHTNKKPKSY QH 552 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IMP:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0010960; P:magnesium ion homeostasis; IMP:MGI.
 GO:0015693; P:magnesium ion transport; IEA:Compara. 
Interpro
 IPR000644; Cysta_beta_synth_core.
 IPR002550; DUF21.
 IPR014710; RmlC-like_jellyroll. 
Pfam
 PF01595; DUF21 
SMART
  
PROSITE
 PS51371; CBS 
PRINTS