| Tag | Content |
|---|
| CPLM ID | CPLM-000671 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kunitz-type protease inhibitor 1 |
Protein Synonyms/Alias | Hepatocyte growth factor activator inhibitor type 1; HAI-1 |
Gene Name | SPINT1 |
Gene Synonyms/Alias | HAI1; UNQ223/PRO256 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 172 | AWAGIDLKVQPQEPL | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). |
Sequence Annotation | DOMAIN 57 140 MANSC.
DOMAIN 250 300 BPTI/Kunitz inhibitor 1.
DOMAIN 334 370 LDL-receptor class A.
DOMAIN 391 441 BPTI/Kunitz inhibitor 2.
CARBOHYD 66 66 N-linked (GlcNAc...) (Potential).
CARBOHYD 235 235 N-linked (GlcNAc...) (Potential).
CARBOHYD 523 523 N-linked (GlcNAc...) (Potential).
DISULFID 250 300
DISULFID 259 283
DISULFID 275 296
DISULFID 335 347 By similarity.
DISULFID 342 360 By similarity.
DISULFID 354 369 By similarity.
DISULFID 391 441 By similarity.
DISULFID 400 424 By similarity.
DISULFID 416 437 By similarity. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Polymorphism; Protease inhibitor; Reference proteome; Repeat; Secreted; Serine protease inhibitor; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 529 AA |
Protein Sequence | MAPARTMARA RLAPAGIPAV ALWLLCTLGL QGTQAGPPPA PPGLPAGADC LNSFTAGVPG 60
FVLDTNASVS NGATFLESPT VRRGWDCVRA CCTTQNCNLA LVELQPDRGE DAIAACFLIN 120
CLYEQNFVCK FAPREGFINY LTREVYRSYR QLRTQGFGGS GIPKAWAGID LKVQPQEPLV 180
LKDVENTDWR LLRGDTDVRV ERKDPNQVEL WGLKEGTYLF QLTVTSSDHP EDTANVTVTV 240
LSTKQTEDYC LASNKVGRCR GSFPRWYYDP TEQICKSFVY GGCLGNKNNY LREEECILAC 300
RGVQGGPLRG SSGAQATFPQ GPSMERRHPV CSGTCQPTQF RCSNGCCIDS FLECDDTPNC 360
PDASDEAACE KYTSGFDELQ RIHFPSDKGH CVDLPDTGLC KESIPRWYYN PFSEHCARFT 420
YGGCYGNKNN FEEEQQCLES CRGISKKDVF GLRREIPIPS TGSVEMAVAV FLVICIVVVV 480
AILGYCFFKN QRKDFHGHHH HPPPTPASST VSTTEDTEHL VYNHTTRPL 529 |
Gene Ontology | GO:0005576; C:extracellular region; TAS:ProtInc. GO:0016020; C:membrane; TAS:ProtInc. GO:0004867; F:serine-type endopeptidase inhibitor activity; TAS:ProtInc. GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Compara. GO:0030198; P:extracellular matrix organization; IEA:Compara. GO:0060674; P:placenta blood vessel development; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |