UniProt Accession

 CLD8_MOUSE; Q9Z260 

Genbank Protein ID

 AF087826; BC003868 

Genbank Nucleotide ID

 AAD09761.1; AAH03868.1 

Protein Name

 Claudin-8 

Protein Synonyms/Alias

  

Gene Name

 Cldn8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
221	RSPSIYSKSQYV***	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). 

Sequence Annotation

 REGION 224 225 Interactions with TJP1, TJP2 and TJP3 (By  

Keyword

 Cell junction; Cell membrane; Complete proteome; Membrane; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 225 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005923; C:tight junction; IDA:UniProtKB.
 GO:0042802; F:identical protein binding; ISS:UniProtKB.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0016338; P:calcium-independent cell-cell adhesion; ISS:UniProtKB. 

Interpro

 IPR006187; Claudin.
 IPR003926; Claudin8.
 IPR017974; Claudin_CS.
 IPR004031; PMP22/EMP/MP20/Claudin. 

Pfam

 PF00822; PMP22_Claudin 

SMART

  

PROSITE

 PS01346; CLAUDIN 

PRINTS

 PR01077; CLAUDIN.
 PR01446; CLAUDIN8.