CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023413
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-dependent RNA helicase Ddx1 
Protein Synonyms/Alias
 DEAD box protein 1 
Gene Name
 Ddx1 
Gene Synonyms/Alias
 CG9054 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
531FLRQRGGKHYSCVCLacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity (By similarity). 
Sequence Annotation
 DOMAIN 2 428 Helicase ATP-binding.
 DOMAIN 69 246 B30.2/SPRY.
 DOMAIN 483 676 Helicase C-terminal.
 NP_BIND 46 53 ATP (By similarity).
 MOTIF 370 373 DEAD box.  
Keyword
 ATP-binding; Complete proteome; Exonuclease; Helicase; Hydrolase; Nuclease; Nucleotide-binding; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 727 AA 
Protein Sequence
MTAFEEFGVL PELGMATDEL DWTLPTDVQA EAIPLILGGG DVLMAAETGS GKTGAFCLPI 60
LQIVWETLRD LEEGKAGKGG AIGGAVTPWT MSFFDRGNAL AVTPDGLRCQ SREFKEWHGC 120
RATTGVRGKG KFYFEATVTD EGLCRVGWST QQANLDLGTC RMGFGFGGTG KKSNNRQFDD 180
YGEAFGKADV IGCLLDLKNQ EVSFTKNGQN LGVAFRLPDN LAKETFYPAV VLKNAEMQFN 240
FGKTDFKYAP GNGFVGACQA GPEHSKANPI TGPAAGAPSA KPAPNAPQAI IMEPSRELAE 300
QTYNQIEKFK YHLSNPEVRS LLLIGGVRLE EQKAQLMQGT HIVVGTPGRL EEMINSGLVL 360
LTHCRFFVLD EADALLKQGY TELIDRLHKQ IPKITSDGRR LQMVVCSATL HAFEVKKMAE 420
RLMHFPTWVD LKGEDAVPET VHHVVCLVDP QMDTTWQSLR QPIGTDGVHD RDNVHPGNHS 480
KETLSQAVKL LKGEYCVHAI DKHNMDRAII FCRTKQDCDN LERFLRQRGG KHYSCVCLHG 540
DRKPQERKEN LEMFKRQQVK FLICTDVAAR GLDITGLPFM INVTLPDDKT NYVHRIGRVG 600
RAERMGLAIS LVATVPEKVW YHGEWCKSRG RSCNNTNLTE VRGCCIWYNE PNLLAEVEDH 660
LNITIQQVDK TMDVPVNDFD GKVVYGQKNL RTGSGYEDHV EQLVPTVRKL TELELQSQSL 720
FLKRLKV 727 
Gene Ontology
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; ISS:UniProtKB.
 GO:0003682; F:chromatin binding; ISS:UniProtKB.
 GO:0033677; F:DNA/RNA helicase activity; ISS:UniProtKB.
 GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
 GO:0004518; F:nuclease activity; ISS:UniProtKB.
 GO:0008143; F:poly(A) RNA binding; ISS:UniProtKB.
 GO:0003712; F:transcription cofactor activity; ISS:UniProtKB.
 GO:0032508; P:DNA duplex unwinding; ISS:UniProtKB.
 GO:0006302; P:double-strand break repair; ISS:UniProtKB.
 GO:0001700; P:embryonic development via the syncytial blastoderm; IEP:UniProtKB.
 GO:0042254; P:ribosome biogenesis; ISS:FlyBase. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR014014; RNA_helicase_DEAD_Q_motif.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF00270; DEAD
 PF00271; Helicase_C
 PF00622; SPRY 
SMART
 SM00487; DEXDc
 SM00490; HELICc
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS