| Tag | Content |
|---|
| CPLM ID | CPLM-010101 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dihydrolipoyl dehydrogenase |
Protein Synonyms/Alias | Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex |
Gene Name | pdhD |
Gene Synonyms/Alias | MPN_390; MP448 |
Created Date | July 27, 2013 |
Organism | Mycoplasma pneumoniae (strain ATCC 29342 / M129) |
NCBI Taxa ID | 272634 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 92 | QKGKVVSKLVGGVKA | acetylation | [1] | | 105 | KAIIASAKAETVMGE | acetylation | [1] | | 126 | NTVEVAGKTYTTKSI | acetylation | [1] | | 328 | AVNHILNKKQVKPAQ | acetylation | [1] | | 360 | GYTEMELKKQGIPYV | acetylation | [1] |
|
Reference | [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium. van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC. Mol Syst Biol. 2012 Feb 28;8:571. [ PMID: 22373819] |
Functional Description | Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes (By similarity). |
Sequence Annotation | NP_BIND 32 40 FAD (By similarity).
NP_BIND 178 182 NAD (By similarity).
NP_BIND 262 265 NAD (By similarity).
ACT_SITE 437 437 Proton acceptor (By similarity).
BINDING 49 49 FAD (By similarity).
BINDING 113 113 FAD; via amide nitrogen and carbonyl
BINDING 235 235 NAD; via amide nitrogen (By similarity).
BINDING 303 303 FAD (By similarity).
BINDING 311 311 FAD; via amide nitrogen (By similarity).
DISULFID 40 45 Redox-active (By similarity). |
Keyword | Complete proteome; Cytoplasm; Disulfide bond; FAD; Flavoprotein; Glycolysis; NAD; Oxidoreductase; Redox-active center; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 457 AA |
Protein Sequence | MNYDLIIIGA GPAGYVAAEY AGKHKLKTLV VEKEYFGGVC LNVGCIPTKT LLKRAKIVDY 60
LRHAQDYGIS INGQVALNWN QLLEQKGKVV SKLVGGVKAI IASAKAETVM GEAKVLDPNT 120
VEVAGKTYTT KSIVVATGSR PRYLTLPGFA EARQNGFVID STQALSLEGV PRKLVVVGGG 180
VIGIEFAFLY ASLGSEVTIL QGVDRILEIF DTEVSDLVAK LLQTKNVKII TNAQVTRANN 240
NEVFYSQNGQ EGSVVGDRIL VSIGRIPNTE CLDGLNLQRD ERNRIVLNQD LQTSIPNIYI 300
VGDANAQLML AHFAYQQGRY AVNHILNKKQ VKPAQKLTCP SCIYTNPEVA SVGYTEMELK 360
KQGIPYVKTN LVLAHCGKAI ADNETNGFVK MMFDPQTGKI LGCCIIAATA SDMIAELALA 420
MGAGLTVFDI ANSISPHPTI NEMIADVCKK ALFDHFK 457 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004148; F:dihydrolipoyl dehydrogenase activity; IEA:EC. GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro. GO:0045454; P:cell redox homeostasis; IEA:InterPro. GO:0006096; P:glycolysis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |