| Tag | Content |
|---|
| CPLM ID | CPLM-015676 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Multivesicular body subunit 12A |
Protein Synonyms/Alias | ESCRT-I complex subunit MVB12A; Protein FAM125A |
Gene Name | Mvb12a |
Gene Synonyms/Alias | Fam125a |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 121 | DVVVSDVKLSGKTKT | ubiquitination | [1] | | 250 | KSLADIEKEYNYGFV | ubiquitination | [1] | | 260 | NYGFVVEKTAAARLP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor (By similarity). |
Sequence Annotation | DOMAIN 7 149 MABP.
DOMAIN 213 263 UMA.
REGION 190 271 Interaction with TSG101, VPS37B and VPS28
MOTIF 153 158 SH3-binding.
MOD_RES 128 128 Phosphothreonine (By similarity).
MOD_RES 161 161 Phosphoserine (By similarity).
MOD_RES 168 168 Phosphoserine.
MOD_RES 200 200 Phosphoserine.
MOD_RES 202 202 Phosphotyrosine (By similarity).
MOD_RES 205 205 Phosphoserine (By similarity). |
Keyword | Complete proteome; Cytoplasm; Cytoskeleton; Endosome; Membrane; Nucleus; Phosphoprotein; Protein transport; Reference proteome; SH3-binding; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 271 AA |
Protein Sequence | MDPGTDSAPL AGLVWSSASA PPPPGFSAIT CTVEGGTASF GRGFAQKAGY FLCLSTLGIP 60
ENPQDNVVVD MQIVMDKGPL PSGFSAVNDP QDIKASVSKK KRMCVKLMPL GTADVVVSDV 120
KLSGKTKTVP GYLRVGDIGG FAIWCKKSKA PRPVPKPRTL SQDMRGLSLD PPKEPSKGSH 180
PERTLSRLGS RASTLRRTDS IYEASSLYGI SAMDGVPFTL HPRFEGKSCG PLNLSAFGDL 240
TIKSLADIEK EYNYGFVVEK TAAARLPPSV S 271 |
Gene Ontology | GO:0016235; C:aggresome; IEA:Compara. GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
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PRINTS | |