UniProt Accession

 BCL10_HUMAN; O95999; Q5VUF1 

Genbank Protein ID

 AJ006288; AF057700; AF100338; AF127386; AF134395; AF105066; AF082283; AF097732; AK291346; AL590113; CH471097; BC053617 

Genbank Nucleotide ID

 CAA06955.1; AAD15800.1; AAD16428.1; AAD32597.1; AAD39147.1; AAF06894.1; AAC99767.1; AAD24918.1; BAF84035.1; CAH71557.1; EAW73208.1; AAH53617.1 

Protein Name

 B-cell lymphoma/leukemia 10 

Protein Synonyms/Alias

 B-cell CLL/lymphoma 10; Bcl-10; CARD-containing molecule enhancing NF-kappa-B; CARD-like apoptotic protein; hCLAP; CED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMEN; Cellular-E10; c-E10; Mammalian CARD-containing adapter molecule E10; mE10 

Gene Name

 BCL10 

Gene Synonyms/Alias

 CIPER; CLAP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
118	LEHLKGLKCSSCEPF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1. 

Sequence Annotation

 DOMAIN 13 101 CARD.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 138 138 Phosphoserine.  

Keyword

 Acetylation; Apoptosis; Chromosomal rearrangement; Complete proteome; Cytoplasm; Disease mutation; Membrane; Phosphoprotein; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 233 AA 

Protein Sequence

Gene Ontology

 GO:0032449; C:CBM complex; NAS:UniProtKB.
 GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0051059; F:NF-kappaB binding; IDA:UniProtKB.
 GO:0019901; F:protein kinase binding; IDA:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0043130; F:ubiquitin binding; IDA:UniProtKB.
 GO:0002250; P:adaptive immune response; TAS:UniProtKB.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; IDA:UniProtKB.
 GO:0006968; P:cellular defense response; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.
 GO:0016064; P:immunoglobulin mediated immune response; IEA:Compara.
 GO:0045087; P:innate immune response; IEP:UniProtKB.
 GO:0042226; P:interleukin-6 biosynthetic process; NAS:UniProtKB.
 GO:0042109; P:lymphotoxin A biosynthetic process; NAS:UniProtKB.
 GO:0002906; P:negative regulation of mature B cell apoptotic process; IDA:UniProtKB.
 GO:0001843; P:neural tube closure; ISS:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.
 GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IMP:UniProtKB.
 GO:0032765; P:positive regulation of mast cell cytokine production; NAS:UniProtKB.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
 GO:0042327; P:positive regulation of phosphorylation; IDA:UniProtKB.
 GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
 GO:0050870; P:positive regulation of T cell activation; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
 GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:Compara.
 GO:0009620; P:response to fungus; IEA:Compara.
 GO:0002237; P:response to molecule of bacterial origin; IEP:UniProtKB.
 GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB.
 GO:0002224; P:toll-like receptor signaling pathway; IC:UniProtKB. 

Interpro

 IPR001315; CARD.
 IPR011029; DEATH-like_dom. 

Pfam

 PF00619; CARD 

SMART

  

PROSITE

 PS50209; CARD 

PRINTS