UniProt Accession

 PLS3_HUMAN; Q9NRY6; A8K252; Q567U0; Q8NBW6; Q96F13 

Genbank Protein ID

 AF159442; AK075188; AK290117; CH471108; AC113189; BC011735; BC093026 

Genbank Nucleotide ID

 AAF91083.1; BAC11458.1; BAF82806.1; EAW90200.1; AAH11735.1; AAH93026.1 

Protein Name

 Phospholipid scramblase 3 

Protein Synonyms/Alias

 PL scramblase 3; Ca(2+)-dependent phospholipid scramblase 3 

Gene Name

 PLSCR3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
238	RSVGRISKQWGGLVR	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages. 

Sequence Annotation

 MOTIF 7 15 SH3-binding 1 (Potential).
 MOTIF 15 18 WW-binding (Potential).
 MOTIF 21 27 SH3-binding 2 (Potential).
 MOTIF 65 70 SH3-binding 3 (Potential).
 MOD_RES 21 21 Phosphothreonine; by PKC/PRKCD.
 LIPID 211 211 S-palmitoyl cysteine (Probable).
 LIPID 214 214 S-palmitoyl cysteine (Probable).
 LIPID 216 216 S-palmitoyl cysteine (Probable).  

Keyword

 Apoptosis; Calcium; Complete proteome; Lipoprotein; Membrane; Mitochondrion; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3-binding; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005509; F:calcium ion binding; NAS:UniProtKB.
 GO:0017128; F:phospholipid scramblase activity; NAS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0017121; P:phospholipid scrambling; NAS:UniProtKB. 

Interpro

 IPR005552; Scramblase. 

Pfam

 PF03803; Scramblase 

SMART

  

PROSITE

  

PRINTS