CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009763
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable glutamine synthetase 2 
Protein Synonyms/Alias
 Glutamate--ammonia ligase 2 
Gene Name
 glnA2 
Gene Synonyms/Alias
 Rv2222c; MT2280; MTCY190.33c; MTCY427.03c 
Created Date
 July 27, 2013 
Organism
 Mycobacterium tuberculosis 
NCBI Taxa ID
 1773 
Lysine Modification
Position
Peptide
Type
References
363AGLRGVEKGYVLGPQpupylation[1]
Reference
 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036] 
Functional Description
  
Sequence Annotation
 CROSSLNK 363 363 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Isopeptide bond; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 446 AA 
Protein Sequence
MDRQKEFVLR TLEERDIRFV RLWFTDVLGF LKSVAIAPAE LEGAFEEGIG FDGSSIEGFA 60
RVSESDTVAH PDPSTFQVLP WATSSGHHHS ARMFCDITMP DGSPSWADPR HVLRRQLTKA 120
GELGFSCYVH PEIEFFLLKP GPEDGSVPVP VDNAGYFDQA VHDSALNFRR HAIDALEFMG 180
ISVEFSHHEG APGQQEIDLR FADALSMADN VMTFRYVIKE VALEEGARAS FMPKPFGQHP 240
GSAMHTHMSL FEGDVNAFHS ADDPLQLSEV GKSFIAGILE HACEISAVTN QWVNSYKRLV 300
QGGEAPTAAS WGAANRSALV RVPMYTPHKT SSRRVEVRSP DSACNPYLTF AVLLAAGLRG 360
VEKGYVLGPQ AEDNVWDLTP EERRAMGYRE LPSSLDSALR AMEASELVAE ALGEHVFDFF 420
LRNKRTEWAN YRSHVTPYEL RTYLSL 446 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:MTBBASE.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0050001; F:D-glutaminase activity; IDA:MTBBASE.
 GO:0004356; F:glutamate-ammonia ligase activity; IEA:EC.
 GO:0006542; P:glutamine biosynthetic process; IEA:InterPro.
 GO:0051260; P:protein homooligomerization; IPI:MTBBASE. 
Interpro
 IPR008147; Gln_synt_beta.
 IPR014746; Gln_synth/guanido_kin_cat_dom.
 IPR008146; Gln_synth_cat_dom.
 IPR027303; Gln_synth_gly_rich_site. 
Pfam
 PF00120; Gln-synt_C
 PF03951; Gln-synt_N 
SMART
  
PROSITE
 PS00180; GLNA_1
 PS00181; GLNA_ATP 
PRINTS