UniProt Accession

 GMPPA_HUMAN; Q96IJ6; A6NJ74; A8K3Q6; B3KMT4; Q53GI0; Q9NWC3; Q9Y5P5 

Genbank Protein ID

 AF135422; AK000999; AK022578; AK290671; AK222951; AC053503; CH471063; CH471063; BC007456 

Genbank Nucleotide ID

 AAD38517.1; BAA91460.1; BAG51096.1; BAF83360.1; BAD96671.1; AAY15053.1; EAW70755.1; EAW70759.1; AAH07456.1 

Protein Name

 Mannose-1-phosphate guanyltransferase alpha 

Protein Synonyms/Alias

 GDP-mannose pyrophosphorylase A; GTP-mannose-1-phosphate guanylyltransferase alpha 

Gene Name

 GMPPA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	ILIGGPQKGTRFRPL	ubiquitination	[1, 2]
275	THPERLAKHTPGGPW	ubiquitination	[1]
347	VYIHPTAKVAPSAVL	ubiquitination	[1]
362	GPNVSIGKGVTVGEG	ubiquitination	[1, 2]
429	MDSESLFKDGKLLPA	ubiquitination	[1, 2]
432	ESLFKDGKLLPAITI	ubiquitination	[1]
461	NSIVLPHKELSRSFT	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; GTP-binding; Nucleotide-binding; Nucleotidyltransferase; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 420 AA 

Protein Sequence

Gene Ontology

 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:EC.
 GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; TAS:Reactome.
 GO:0009298; P:GDP-mannose biosynthetic process; TAS:Reactome.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome. 

Interpro

 IPR001451; Hexapep_transf.
 IPR018357; Hexapep_transf_CS.
 IPR005835; NTP_transferase. 

Pfam

 PF00132; Hexapep
 PF00483; NTP_transferase 

SMART

  

PROSITE

 PS00101; HEXAPEP_TRANSFERASES 

PRINTS