CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008575
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60S ribosomal protein L10a 
Protein Synonyms/Alias
 CSA-19; Neural precursor cell expressed developmentally down-regulated protein 6; NEDD-6 
Gene Name
 Rpl10a 
Gene Synonyms/Alias
 Nedd-6; Nedd6 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
91HMDIEALKKLNKNKKacetylation[1, 2, 3, 4, 5]
91HMDIEALKKLNKNKKubiquitination[6]
106LVKKLAKKYDAFLASacetylation[7]
152VAKVDEVKSTIKFQMubiquitination[6]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [7] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647
Functional Description
  
Sequence Annotation
 MOD_RES 11 11 Phosphotyrosine.
 MOD_RES 106 106 N6-acetyllysine.
 MOD_RES 118 118 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 217 AA 
Protein Sequence
MSSKVSRDTL YEAVREVLHG NQRKRRKFLE TVELQISLKN YDPQKDKRFS GTVRLKSTPR 60
PKFSVCVLGD QQHCDERKAV DIPHMDIEAL KKLNKNKKLV KKLAKKYDAF LASESLIKQI 120
PRILGPGLNK AGKFPSLLTH NENMVAKVDE VKSTIKFQMK KVLCLAVAVG HVKMTDDELV 180
YNIHLAVNFL VSLLKKNWQN VRALYIKSTM GKPQRLY 217 
Gene Ontology
 GO:0015934; C:large ribosomal subunit; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0006412; P:translation; IEA:InterPro. 
Interpro
 IPR002143; Ribosomal_L1.
 IPR016094; Ribosomal_L1_2-a/b-sand.
 IPR016095; Ribosomal_L1_3-a/b-sand.
 IPR023673; Ribosomal_L1_CS.
 IPR023674; Ribosomal_L1_SF. 
Pfam
 PF00687; Ribosomal_L1 
SMART
  
PROSITE
 PS01199; RIBOSOMAL_L1 
PRINTS