CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041608
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RCG57812, isoform CRA_b 
Protein Synonyms/Alias
 STE20-like serine/threonine-protein kinase 
Gene Name
 Slk 
Gene Synonyms/Alias
 rCG_57812 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
916EQEKELSKFQNMLRNacetylation[1]
996QLLKQQLKDQYFIQRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1203 AA 
Protein Sequence
MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA 60
AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120
LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180
TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240
MRVLLKIAKS EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPV 300
RELIAEAKAE VTEEVEDGKE EDDDDETESA LPIPANKRAS SDLSIASSEE DKLSQNACIL 360
ESVSERTEHN TSGDKFSNKV LSEKPTPEGP EKAVDVDGPA NDVNLETVAE PNDQAVGFHE 420
NGREKKRPKL ESQPDTEDQQ TVDVNLVGEG NDSNIVILET NTDCLKPEED RNEENQEIIE 480
NKLTQSEEIK DIHIQTMDLV SQETGEKEAD FQAIDNEVGF TKEETQEKLG KDDKTQKVVI 540
SDISSEVGTD EAPGDTQKAA EQSQDAEGGA GEEAPEPAQT LTEKATEGPE AHGAEEEPRS 600
GERVEDKQLE QQSAVCEGEG QVTSTSESTR ATTEEPETDE VDQVSESNSI EELERLGVTG 660
AEEQALGSKG EAATEVDLER EENAQELPIK AEPQAPAASQ PSEPPPVLIP SINIHSENTE 720
NKGEMGALPK PETILPPEPE NGKGNDTDSG TGSTVENSSS DLNLSISSFL SKTKDSGSVS 780
LQETRRQKKT LKKTRKFIVD GVEVSVTTSK IVTDSDSKTE ELRFLRRQEL RELRLLQKEE 840
QKAQQQLNGK LQQQREQIFR RFEQEMLSKK RQYDQEIENL EKQQKQTIER LEQEHTNRLR 900
DEAKRIKGEQ EKELSKFQNM LRNRKKEEQE FVQKQQQELD GALKKIIQQQ KAELANIERE 960
CLNNKQQLLR AREAAIWELE ERHLQEKHQL LKQQLKDQYF IQRHQLLKRH EKETEQMQRY 1020
NQRLIEELKN RQTQERARLP KIQRSEAKTR MAMFKKSLRI NSTATPDQDR EKIKQFAAQE 1080
EKRQKNERMA QHQKHESQMR DLQLQCEANV RELHQLQNEK CHLLVEHETQ KLKELDEEHS 1140
QELKEWREKL RPRKKTLEEE FARKLQEQEV FFKMTGESEC LNPSAQSRIS KFYPIPTLHS 1200
TGS 1203 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR022165; PKK.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS.
 IPR001943; UVR_dom. 
Pfam
 PF00069; Pkinase
 PF12474; PKK 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50151; UVR 
PRINTS