CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003928
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-acetyl-gamma-glutamyl-phosphate reductase 
Protein Synonyms/Alias
 AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase 
Gene Name
 argC 
Gene Synonyms/Alias
 b3958; JW3930 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
43AQSNDAGKLISDLHPacetylation[1]
267LQQAYAHKPLVRLYDacetylation[1]
275PLVRLYDKGVPALKNacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 ACT_SITE 154 154 By similarity.  
Keyword
 Amino-acid biosynthesis; Arginine biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 334 AA 
Protein Sequence
MLNTLIVGAS GYAGAELVTY VNRHPHMNIT ALTVSAQSND AGKLISDLHP QLKGIVDLPL 60
QPMSDISEFS PGVDVVFLAT AHEVSHDLAP QFLEAGCVVF DLSGAFRVND ATFYEKYYGF 120
THQYPELLEQ AAYGLAEWCG NKLKEANLIA VPGCYPTAAQ LALKPLIDAD LLDLNQWPVI 180
NATSGVSGAG RKAAISNSFC EVSLQPYGVF THRHQPEIAT HLGADVIFTP HLGNFPRGIL 240
ETITCRLKSG VTQAQVAQVL QQAYAHKPLV RLYDKGVPAL KNVVGLPFCD IGFAVQGEHL 300
IIVATEDNLL KGAAAQAVQC ANIRFGYAET QSLI 334 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IDA:EcoCyc.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0006526; P:arginine biosynthetic process; IDA:EcoCyc. 
Interpro
 IPR023013; AGPR_AS.
 IPR000706; AGPR_type-1.
 IPR016040; NAD(P)-bd_dom.
 IPR000534; Semialdehyde_DH_NAD-bd.
 IPR012280; Semialdhyde_DH_dimer_dom. 
Pfam
 PF01118; Semialdhyde_dh
 PF02774; Semialdhyde_dhC 
SMART
 SM00859; Semialdhyde_dh 
PROSITE
 PS01224; ARGC 
PRINTS