UniProt Accession

 B4DNW0_HUMAN; B4DNW0 

Genbank Protein ID

 AC115284; AK298086 

Genbank Nucleotide ID

 BAG60372.1 

Protein Name

 Aminoacylase-1 

Protein Synonyms/Alias

 cDNA FLJ60317, highly similar to Aminoacylase-1 (EC 3.5.1.14) 

Gene Name

 ACY1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
94	TRSAMTSKGPEEEHP	ubiquitination	[1]
118	RIRTVQPKPDYGAAV	ubiquitination	[1]
190	HDPFEAFKDSEGYIY	ubiquitination	[1, 2]
205	ARGAQDMKCVSIQYL	ubiquitination	[1, 2]
219	LEAVRRLKVEGHRFP	ubiquitination	[2]
308	MEDTAAEKLHKVVNS	ubiquitination	[1]
311	TAAEKLHKVVNSILA	ubiquitination	[1]
334	LQSNPHLKEGSVTSV	ubiquitination	[1, 2, 3]
345	VTSVNLTKLEGGVAY	ubiquitination	[2]
422	AAFSRVCKDMNLTLE	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 498 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004046; F:aminoacylase activity; IEA:InterPro.
 GO:0008237; F:metallopeptidase activity; IEA:InterPro.
 GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 

Interpro

 IPR001261; ArgE/DapE_CS.
 IPR010159; N-acyl_aa_amidohydrolase.
 IPR002933; Peptidase_M20.
 IPR011650; Peptidase_M20_dimer. 

Pfam

 PF07687; M20_dimer
 PF01546; Peptidase_M20 

SMART

  

PROSITE

 PS00758; ARGE_DAPE_CPG2_1
 PS00759; ARGE_DAPE_CPG2_2 

PRINTS