UniProt Accession

 SH24A_HUMAN; Q9H788; B4DDR1; Q5XKC1; Q6NXE9; Q86YM2; Q96C88; Q9H7F7 

Genbank Protein ID

 AK024620; AK024799; AK293301; AC068880; BC014525; BC067117; BC082982; AY190323 

Genbank Nucleotide ID

 BAB14935.1; BAB15010.1; BAG56822.1; AAH14525.2; AAH67117.1; AAH82982.1; AAO41715.1 

Protein Name

 SH2 domain-containing protein 4A 

Protein Synonyms/Alias

 Protein SH(2)A; Protein phosphatase 1 regulatory subunit 38 

Gene Name

 SH2D4A 

Gene Synonyms/Alias

 PPP1R38; SH2A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	NGKSVHWKLGADKEV	acetylation	[1]
115	QEAEEPRKTHSEEFT	ubiquitination	[2]
126	EEFTNSLKTKSQYHD	ubiquitination	[2]
327	EDIIRWFKEEQLPLR	ubiquitination	[2, 3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function. 

Sequence Annotation

 DOMAIN 347 440 SH2.
 MOD_RES 261 261 Phosphoserine.
 MOD_RES 315 315 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 454 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0019902; F:phosphatase binding; IDA:UniProtKB.
 GO:0010923; P:negative regulation of phosphatase activity; IDA:UniProtKB. 

Interpro

 IPR000980; SH2. 

Pfam

 PF00017; SH2 

SMART

 SM00252; SH2 

PROSITE

 PS50001; SH2 

PRINTS