UniProt Accession

 ARP9_YEAST; Q05123; D6VZK8 

Genbank Protein ID

 Z49213; BK006946 

Genbank Nucleotide ID

 CAA89149.1; DAA09932.1 

Protein Name

 Actin-like protein ARP9 

Protein Synonyms/Alias

 Chromatin structure-remodeling complex protein ARP9; SWI/SNF complex component ARP9 

Gene Name

 ARP9 

Gene Synonyms/Alias

 SWP59; YMR033W; YM9973.07 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
386	AATKKKSKFMTNSTA	acetylation	[1]
444	KQIFTHPKDTFYITR	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in transcriptional regulation. Heterodimer of ARP9 and ARP7 functions with HMG box proteins to facilitate proper chromatin architecture. Heterodimer formation is necessary for assembly into RSC complex. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. 

Sequence Annotation

  

Keyword

 3D-structure; Chromatin regulator; Complete proteome; Direct protein sequencing; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 467 AA 

Protein Sequence

Gene Ontology

 GO:0016586; C:RSC complex; IDA:UniProtKB.
 GO:0016514; C:SWI/SNF complex; IDA:UniProtKB.
 GO:0005198; F:structural molecule activity; IMP:UniProtKB.
 GO:0043044; P:ATP-dependent chromatin remodeling; IDA:UniProtKB.
 GO:0006337; P:nucleosome disassembly; IDA:SGD.
 GO:0042766; P:nucleosome mobilization; IDA:SGD.
 GO:0016584; P:nucleosome positioning; IMP:SGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:SGD. 

Interpro

 IPR004000; Actin-related. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

  

PRINTS