CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014730
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein fantom 
Protein Synonyms/Alias
 Nephrocystin-8; RPGR-interacting protein 1-like protein; RPGRIP1-like protein 
Gene Name
 RPGRIP1L 
Gene Synonyms/Alias
 FTM; KIAA1005; NPHP8 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
761GYITSNFKGPEHMQSubiquitination[1]
1227ILKAILQKQEMPNRSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1 and NPHP4 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). 
Sequence Annotation
 DOMAIN 615 712 C2 1.
 DOMAIN 777 881 C2 2.  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell projection; Ciliopathy; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Joubert syndrome; Meckel syndrome; Polymorphism; Reference proteome; Repeat; Tight junction. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1315 AA 
Protein Sequence
MSGPTDETAG DLPVKDTGLN LFGMGGLQET STTRTMKSRQ AVSRVSREEL EDRFLRLHDE 60
NILLKQHARK QEDKIKRMAT KLIRLVNDKK RYERVGGGPK RLGRDVEMEE MIEQLQEKVH 120
ELEKQNETLK NRLISAKQQL QTQGYRQTPY NNVQSRINTG RRKANENAGL QECPRKGIKF 180
QDADVAETPH PMFTKYGNSL LEEARGEIRN LENVIQSQRG QIEELEHLAE ILKTQLRRKE 240
NEIELSLLQL REQQATDQRS NIRDNVEMIK LHKQLVEKSN ALSAMEGKFI QLQEKQRTLR 300
ISHDALMANG DELNMQLKEQ RLKCCSLEKQ LHSMKFSERR IEELQDRIND LEKERELLKE 360
NYDKLYDSAF SAAHEEQWKL KEQQLKVQIA QLETALKSDL TDKTEILDRL KTERDQNEKL 420
VQENRELQLQ YLEQKQQLDE LKKRIKLYNQ ENDINADELS EALLLIKAQK EQKNGDLSFL 480
VKVDSEINKD LERSMRELQA THAETVQELE KTRNMLIMQH KINKDYQMEV EAVTRKMENL 540
QQDYELKVEQ YVHLLDIRAA RIHKLEAQLK DIAYGTKQYK FKPEIMPDDS VDEFDETIHL 600
ERGENLFEIH INKVTFSSEV LQASGDKEPV TFCTYAFYDF ELQTTPVVRG LHPEYNFTSQ 660
YLVHVNDLFL QYIQKNTITL EVHQAYSTEY ETIAACQLKF HEILEKSGRI FCTASLIGTK 720
GDIPNFGTVE YWFRLRVPMD QAIRLYRERA KALGYITSNF KGPEHMQSLS QQAPKTAQLS 780
STDSTDGNLN ELHITIRCCN HLQSRASHLQ PHPYVVYKFF DFADHDTAII PSSNDPQFDD 840
HMYFPVPMNM DLDRYLKSES LSFYVFDDSD TQENIYIGKV NVPLISLAHD RCISGIFELT 900
DHQKHPAGTI HVILKWKFAY LPPSGSITTE DLGNFIRSEE PEVVQRLPPA SSVSTLVLAP 960
RPKPRQRLTP VDKKVSFVDI MPHQSDETSP PPEDRKEISP EVEHIPEIEI NMLTVPHVPK 1020
VSQEGSVDEV KENTEKMQQG KDDVSLLSEG QLAEQSLASS EDETEITEDL EPEVEEDMSA 1080
SDSDDCIIPG PISKNIKQSL ALSPGLGCSS AISAHCNFRL PGSSDFPASA SQVDGITGAC 1140
HHTQPSEKIR IEIIALSLND SQVTMDDTIQ RLFVECRFYS LPAEETPVSL PKPKSGQWVY 1200
YNYSNVIYVD KENNKAKRDI LKAILQKQEM PNRSLRFTVV SDPPEDEQDL ECEDIGVAHV 1260
DLADMFQEGR DLIEQNIDVF DARADGEGIG KLRVTVEALH ALQSVYKQYR DDLEA 1315 
Gene Ontology
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0035085; C:cilium axoneme; IDA:MGI.
 GO:0005932; C:microtubule basal body; IDA:MGI.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
 GO:0043010; P:camera-type eye development; IEA:Compara.
 GO:0021549; P:cerebellum development; IEA:Compara.
 GO:0042384; P:cilium assembly; IEA:Compara.
 GO:0022038; P:corpus callosum development; IEA:Compara.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0035116; P:embryonic hindlimb morphogenesis; IEA:Compara.
 GO:0060322; P:head development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0021670; P:lateral ventricle development; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.
 GO:0021532; P:neural tube patterning; IEA:Compara.
 GO:0043584; P:nose development; IEA:Compara.
 GO:0021772; P:olfactory bulb development; IEA:Compara.
 GO:0060039; P:pericardium development; IEA:Compara.
 GO:0008589; P:regulation of smoothened signaling pathway; IEA:Compara. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR021656; DUF3250. 
Pfam
 PF00168; C2
 PF11618; DUF3250 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2 
PRINTS