| Tag | Content |
|---|
| CPLM ID | CPLM-023576 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA replication licensing factor Mcm3 |
Protein Synonyms/Alias | Minichromosome maintenance 3 protein; DmMCM3 |
Gene Name | Mcm3 |
Gene Synonyms/Alias | Mcm3-RA; CG4206 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 548 | YDALLHGKSRQRHEK | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Acts as component of the Mcm2-7 complex (Mcm complex) (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP- binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. |
Sequence Annotation | DOMAIN 290 496 MCM.
NP_BIND 340 347 ATP (Potential).
MOTIF 472 475 Arginine finger.
MOD_RES 522 522 Phosphoserine.
MOD_RES 538 538 Phosphotyrosine.
MOD_RES 664 664 Phosphoserine.
MOD_RES 666 666 Phosphoserine.
MOD_RES 680 680 Phosphoserine.
MOD_RES 682 682 Phosphoserine.
MOD_RES 690 690 Phosphothreonine.
MOD_RES 692 692 Phosphothreonine.
MOD_RES 697 697 Phosphoserine.
MOD_RES 735 735 Phosphoserine.
MOD_RES 739 739 Phosphoserine. |
Keyword | ATP-binding; Cell cycle; Complete proteome; DNA replication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 819 AA |
Protein Sequence | MAHEGEQFIK DIQREYVDFL DDEEDQGIYA GHVKDMIAEK SKRLIVNVND LKRKNPQRAL 60
GLLSNAADEQ LAFGRALKEY ASTVDPGYAK MHEDLFVGFE GCFGNRHVTP RSLTSIYLGN 120
MVCVEGIVTK VSLIRPKVVR SVHYCPNTRK VMERKYTDLT SFEAVPSGAA YPTKDEDGNL 180
LETEYGLSVY KDHQTLTIQE MPEKAPAGQL PRSVDIVCDD DLVDRCKPGD RVQIVGSYRC 240
LPGKRGGYTS GTFRTVLLAN NISLLSKESN LDISREDIML CKKLAKNNDI FELLSKSLAP 300
SIHGHAYVKQ AILCLLLGGV EKILPNGTRL RGDINVLLIG DPSVAKSQLL RYVLNTAPRA 360
IPTTGRGSSG VGLTAAVTTD QETGERRLEA GAMVLADRGV VCIDEFDKMS DIDRTAIHEV 420
MEQGRVTISK AGIHASLNAR CSVLAAANPV YGRYDQYKTP MENIGLQDSL LSRFDLLFVM 480
LDVIDSDVDQ MISDHVVRMH RYRNPKEADG EPLSMGSSYA DSLSFVSSSE EKKDTEVYEK 540
YDALLHGKSR QRHEKILSVE FMRKYIHIAK CMKPKLGEQA CEAIANEYSR LRSQEAVETD 600
VARTQPITAR TLETLIRLST AHARARMSKS VTIDDAHAAI ELVQFAYFKK VLDKDRPSKR 660
RRNSGSDAED DNGEASSQRS PSRRSKRTRT ATVGADSDEE DIEPPQPDAG DLTRRETRRS 720
LPARSVAMLM ASPSSEEQSV ATSTTEPAII SDARLGEFKN NLQRLFREAR EQSLALARIT 780
TAINVGSQEP FTAGEIEAAV HRMTEDNQIM VADDIVFLI 819 |
Gene Ontology | |
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Pfam | |
SMART | |
PROSITE | |
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