| Tag | Content |
|---|
| CPLM ID | CPLM-022864 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein sel-1 homolog 1 |
Protein Synonyms/Alias | Suppressor of lin-12-like protein 1; Sel-1L |
Gene Name | SEL1L |
Gene Synonyms/Alias | TSA305; UNQ128/PRO1063 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 248 | AAREMFEKLTEEGSP | ubiquitination | [1] | | 440 | TALHYFKKAADMGNP | ubiquitination | [1] | | 504 | IGVKRDYKQALKYFN | ubiquitination | [1] | | 676 | NLGYMHEKGLGIKQD | ubiquitination | [1] | | 681 | HEKGLGIKQDIHLAK | ubiquitination | [1] | | 688 | KQDIHLAKRFYDMAA | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. |
Sequence Annotation | DOMAIN 122 170 Fibronectin type-II.
REPEAT 183 218 Sel1-like 1.
REPEAT 219 254 Sel1-like 2.
REPEAT 255 290 Sel1-like 3.
REPEAT 291 326 Sel1-like 4.
REPEAT 373 409 Sel1-like 5.
REPEAT 410 446 Sel1-like 6.
REPEAT 447 482 Sel1-like 7.
REPEAT 483 518 Sel1-like 8.
REPEAT 519 554 Sel1-like 9.
REPEAT 627 662 Sel1-like 10.
REPEAT 664 699 Sel1-like 11.
REGION 22 737 Interaction with ERLEC1, OS9 and SYVN1.
REGION 738 794 Mediates retention to the endoplasmic
CARBOHYD 195 195 N-linked (GlcNAc...) (Potential).
CARBOHYD 217 217 N-linked (GlcNAc...) (Potential).
CARBOHYD 272 272 N-linked (GlcNAc...).
CARBOHYD 431 431 N-linked (GlcNAc...).
CARBOHYD 608 608 N-linked (GlcNAc...).
DISULFID 127 153 By similarity.
DISULFID 141 168 By similarity. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Membrane; Notch signaling pathway; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 794 AA |
Protein Sequence | MRVRIGLTLL LCAVLLSLAS ASSDEEGSQD ESLDSKTTLT SDESVKDHTT AGRVVAGQIF 60
LDSEESELES SIQEEEDSLK SQEGESVTED ISFLESPNPE NKDYEEPKKV RKPALTAIEG 120
TAHGEPCHFP FLFLDKEYDE CTSDGREDGR LWCATTYDYK ADEKWGFCET EEEAAKRRQM 180
QEAEMMYQTG MKILNGSNKK SQKREAYRYL QKAASMNHTK ALERVSYALL FGDYLPQNIQ 240
AAREMFEKLT EEGSPKGQTA LGFLYASGLG VNSSQAKALV YYTFGALGGN LIAHMVLGYR 300
YWAGIGVLQS CESALTHYRL VANHVASDIS LTGGSVVQRI RLPDEVENPG MNSGMLEEDL 360
IQYYQFLAEK GDVQAQVGLG QLHLHGGRGV EQNHQRAFDY FNLAANAGNS HAMAFLGKMY 420
SEGSDIVPQS NETALHYFKK AADMGNPVGQ SGLGMAYLYG RGVQVNYDLA LKYFQKAAEQ 480
GWVDGQLQLG SMYYNGIGVK RDYKQALKYF NLASQGGHIL AFYNLAQMHA SGTGVMRSCH 540
TAVELFKNVC ERGRWSERLM TAYNSYKDGD YNAAVIQYLL LAEQGYEVAQ SNAAFILDQR 600
EASIVGENET YPRALLHWNR AASQGYTVAR IKLGDYHFYG FGTDVDYETA FIHYRLASEQ 660
QHSAQAMFNL GYMHEKGLGI KQDIHLAKRF YDMAAEASPD AQVPVFLALC KLGVVYFLQY 720
IRETNIRDMF TQLDMDQLLG PEWDLYLMTI IALLLGTVIA YRQRQHQDMP APRPPGPRPA 780
PPQQEGPPEQ QPPQ 794 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; NAS:UniProtKB. GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW. GO:0034976; P:response to endoplasmic reticulum stress; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |