CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010606
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Succinate-semialdehyde dehydrogenase [NADP(+)] 
Protein Synonyms/Alias
 SSDH 
Gene Name
 gabD 
Gene Synonyms/Alias
 ycnH; BSU03910 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
64YELIVEHKEELADLIacetylation[1]
77LITKENGKPYQEAVGacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
 Catalyzes the NADP(+) dependent oxidation of succinate semialdehyde to succinate. 
Sequence Annotation
 NP_BIND 133 134 NADP (By similarity).
 NP_BIND 157 160 NADP (By similarity).
 NP_BIND 210 211 NADP (By similarity).
 ACT_SITE 232 232 Proton acceptor (By similarity).
 ACT_SITE 266 266 Nucleophile (By similarity).
 BINDING 233 233 NADP; via carbonyl oxygen (By
 BINDING 366 366 NADP (By similarity).  
Keyword
 Complete proteome; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 462 AA 
Protein Sequence
MPDQLTVYNP ATGEEIKTIP QQSATEVEEA IERSHQAFKT WSKTSANERT SLLKKWYELI 60
VEHKEELADL ITKENGKPYQ EAVGEVLYGA GYIEWFAEEA KRVYGRTVPA PTTGKRIVVT 120
RQPVGPVAAI TPWNFPNAMI TRKAAPALAA GCTFIIKPAP DTPLSAYELA RLAYEAGIPK 180
DVLQVVIGDG EEIGNVFTSS PKIRKITFTG STPVGKILMK NSADTVKHVS MELGGHAPLI 240
VDEDADIDLA VEQAMASKYR NAGQTCVCAN RLIVHESIKD EFAAKLSEQV SKLKVGNGLE 300
EGVNVGPIIN KRGFEKIVSQ IDDAVEKGAK VIAGGTYDRN DDKGCYFVNP TVLTDVDTSM 360
NIMHEETFGP VAPIVTFSDI DEAIQLANDT PYGLAAYFFT ENYRRGIYIS ENLEYGIIGW 420
NDGGPSAVQA PFGGMKESGI GREGGSEGIE PYLETKYLSI GL 462 
Gene Ontology
 GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
 GO:0009450; P:gamma-aminobutyric acid catabolic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010102; Succ_semiAld_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS