| Tag | Content |
|---|
| CPLM ID | CPLM-023173 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Neurabin-1 |
Protein Synonyms/Alias | Neurabin-I; Neural tissue-specific F-actin-binding protein I; Protein phosphatase 1 regulatory subunit 9A |
Gene Name | PPP1R9A |
Gene Synonyms/Alias | KIAA1222 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 777 | LIKDFQQKELDFIKR | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1- alpha activity (By similarity). |
Sequence Annotation | DOMAIN 504 592 PDZ.
DOMAIN 988 1051 SAM.
REGION 1 144 Actin-binding.
REGION 425 502 Interacts with protein phosphatase 1 (By
REGION 597 1090 Interacts with TGN38 (By similarity).
MOD_RES 338 338 Phosphoserine.
MOD_RES 460 460 Phosphoserine; by PKA (By similarity).
MOD_RES 840 840 Phosphoserine. |
Keyword | 3D-structure; Actin-binding; Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; Synapse; Synaptosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1098 AA |
Protein Sequence | MLKTESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG SQQSRGRKYG 60
SNVNRIKNLF MQMGMEPNEN AAVIAKTRGK GGHSSPQRRM KPKEFLEKTD GSVVKLESSV 120
SERISRFDTM YDGPSYSKFT ETRKMFERSV HESGQNNRYS PKKEKAGGSE PQDEWGGSKS 180
NRGSTDSLDS LSSRTEAVSP TVSQLSAVFE NTDSPSAIIS EKAENNEYSV TGHYPLNLPS 240
VTVTNLDTFG HLKDSNSWPP SNKRGVDTED AHKSNATPVP EVASKSTSLA SIPGEEIQQS 300
KEPEDSTSNQ QTPDSIDKDG PEEPCAESKA MPKSEIPSPQ SQLLEDAEAN LVGREAAKQQ 360
RKELAGGDFT SPDASASSCG KEVPEDSNNF DGSHVYMHSD YNVYRVRSRY NSDWGETGTE 420
QDEEEDSDEN SYYQPDMEYS EIVGLPEEEE IPANRKIKFS SAPIKVFNTY SNEDYDRRND 480
EVDPVAASAE YELEKRVEKL ELFPVELEKD EDGLGISIIG MGVGADAGLE KLGIFVKTVT 540
EGGAAQRDGR IQVNDQIVEV DGISLVGVTQ NFAATVLRNT KGNVRFVIGR EKPGQVSEVA 600
QLISQTLEQE RRQRELLEQH YAQYDADDDE TGEYATDEEE DEVGPVLPGS DMAIEVFELP 660
ENEDMFSPSE LDTSKLSHKF KELQIKHAVT EAEIQKLKTK LQAAENEKVR WELEKTQLQQ 720
NIEENKERML KLESYWIEAQ TLCHTVNEHL KETQSQYQAL EKKYNKAKKL IKDFQQKELD 780
FIKRQEAERK KIEDLEKAHL VEVQGLQVRI RDLEAEVFRL LKQNGTQVNN NNNIFERRTS 840
LGEVSKGDTM ENLDGKQTSC QDGLSQDLNE AVPETERLDS KALKTRAQLS VKNRRQRPSR 900
TRLYDSVSST DGEDSLERKN FTFNDDFSPS STSSADLSGL GAEPKTPGLS QSLALSSDES 960
LDMIDDEILD DGQSPKHSQC QNRAVQEWSV QQVSHWLMSL NLEQYVSEFS AQNITGEQLL 1020
QLDGNKLKAL GMTASQDRAV VKKKLKEMKM SLEKARKAQE KMEKQREKLR RKEQEQMQRK 1080
SKKTEKMTST TAEGAGEQ 1098 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |