CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013202
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 4 
Protein Synonyms/Alias
 Netrin-G2 ligand; NGL-2 
Gene Name
 Lrrc4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
181RLDLGELKKLEYISEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma. 
Sequence Annotation
 DOMAIN 41 74 LRRNT.
 REPEAT 75 96 LRR 1.
 REPEAT 99 120 LRR 2.
 REPEAT 123 144 LRR 3.
 REPEAT 147 168 LRR 4.
 REPEAT 171 193 LRR 5.
 REPEAT 196 217 LRR 6.
 REPEAT 218 239 LRR 7.
 REPEAT 242 263 LRR 8.
 REPEAT 266 287 LRR 9.
 DOMAIN 299 351 LRRCT.
 DOMAIN 352 441 Ig-like C2-type.
 CARBOHYD 321 321 N-linked (GlcNAc...) (Potential).
 CARBOHYD 362 362 N-linked (GlcNAc...) (Potential).
 DISULFID 45 51 By similarity.
 DISULFID 49 60 By similarity.
 DISULFID 303 328 By similarity.
 DISULFID 305 349 By similarity.
 DISULFID 373 423 By similarity.  
Keyword
 Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat; Membrane; Postsynaptic cell membrane; Reference proteome; Repeat; Signal; Synapse; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 652 AA 
Protein Sequence
MKLLWQVTVH HTWNAVLLPV VYLTAQVWIL CAAIAAAASA GPQNCPSVCS CSNQFSKVVC 60
TRRGLSEVPQ GIPSNTRYLN LMENNIQMIQ ADTFRHLHHL EVLQLGRNAI RQIEVGAFNG 120
LASLNTLELF DNWLTVIPSG AFEYLSKLRE LWLRNNPIES IPSYAFNRVP SLMRLDLGEL 180
KKLEYISEGA FEGLFNLKYL NLGMCNIKDM PNLTPLVGLE ELEMSGNHFP EIRPGSFHGL 240
SSLKKLWVMN SQVSLIERNA FDGLASLVEL NLAHNNLSSL PHDLFTPLRY LVELHLHHNP 300
WNCDCDILWL AWWLREYIPT NSTCCGRCHA PMHMRGRYLV EVDQASFQCS APFIMDAPRD 360
LNISEDRMAE LKCRTPPMSS VKWLLPNGTV LSHASRHPRI SVLNDGTLNF SRVLLIDTGV 420
YTCMVTNVAG NSNASAYLNV SSAELNTPNF SFFTTVTVET TEISPEDITR KYKPVPTTST 480
GYQPAYTTST TVLIQTTRVP KQVPVPSTDT TDKMQTSLDE VMKTTKIIIG CFVAVTLLAA 540
AMLIVFYKLR KRHQQRSTVT AARTVEIIQV DEDIPAAASA AATAAPSGVS GEGAVVLPTI 600
HDHINYNTYK PAHGAHWTEN SLGNSLHPTV TTISEPYIIQ THTKDKVQET QI 652 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. 
Interpro
 IPR000483; Cys-rich_flank_reg_C.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N.
 IPR026906; LRR_5.
 IPR026882; Lrrc4. 
Pfam
 PF07679; I-set
 PF13306; LRR_5 
SMART
 SM00408; IGc2
 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 
PROSITE
 PS50835; IG_LIKE
 PS51450; LRR 
PRINTS