CPLM-023654

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-023654

UniProt Accession

DLGP4_HUMAN; Q9Y2H0; E1P5T5; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7

Genbank Protein ID

AB023181; AL390374; AL050318; AL390374; AL050318; AL050318; AL390374; AL050318; AL390374; AL390374; AL050318; AL050318; AL390374; CH471077; CH471077; CH471077; BC108706; BC153874

Genbank Nucleotide ID

BAA76808.2; CAI17927.1; CAI17927.1; CAI17928.1; CAI17928.1; CAI23506.1; CAI23506.1; CAI23507.1; CAI23507.1; CAI17929.1; CAI17929.1; CAI23509.1; CAI23509.1; EAW76140.1; EAW76135.1; EAW76136.1; AAI08707.1; AAI53875.1

Protein Name

Disks large-associated protein 4

Protein Synonyms/Alias

DAP-4; PSD-95/SAP90-binding protein 4; SAP90/PSD-95-associated protein 4; SAPAP-4

Gene Name

DLGAP4

Gene Synonyms/Alias

DAP4; KIAA0964; SAPAP4

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
830	CQMDKETKENNLSEE	acetylation	[1]

Reference

[1] Regulation of cellular metabolism by protein lysine acetylation.
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]

Functional Description

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

Sequence Annotation

MOD_RES 368 368 Phosphoserine (By similarity).
MOD_RES 378 378 Phosphoserine (By similarity).
MOD_RES 397 397 Phosphoserine (By similarity).
MOD_RES 421 421 Phosphoserine (By similarity).
MOD_RES 512 512 Phosphoserine (By similarity).
MOD_RES 665 665 Phosphoserine (By similarity).
MOD_RES 915 915 Phosphothreonine.
MOD_RES 973 973 Phosphoserine.

Keyword

Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

992 AA

Protein Sequence

MKGLGDSRPR HLSDSLDPPH EPLFAGTDRN PYLLSPTEAF AREARFPGQN TLPGDGLFPL 60
NNQLPPPSST FPRIHYNSHF EVPEESPFPS HAQATKINRL PANLLDQFEK QLPIHRDGFS 120
TLQFPRGEAK ARGESPGRIR HLVHSVQRLF FTKAPSLEGT AGKVGGNGSK KGGMEDGKGR 180
RAKSKERAKA GEPKRRSRSN ISGWWSSDDN LDGEAGAFRS SGPASGLMTL GRQAERSQPR 240
YFMHAYNTIS GHMLKTTKNN TTELTAPPPP PAPPATCPSL GVGTDTNYVK RGSWSTLTLS 300
HAHEVCQKTS ATLDKSLLKS KSCHQGLAYH YLQVPGGGGE WSTTLLSPRE TDAAAEGPIP 360
CRRMRSGSYI KAMGDEDSDE SGGSPKPSPK TAARRQSYLR ATQQSLGEQS NPRRSLDRLD 420
SVDMLLPSKC PSWEEDYTPV SDSLNDSSCI SQIFGQASLI PQLFGHEQQV REAELSDQYE 480
AACESACSEA ESTAAETLDL PLPSYFRSRS HSYLRAIQAG CSQEEDSVSL QSLSPPPSTG 540
SLSNSRTLPS SSCLVAYKKT PPPVPPRTTS KPFISVTVQS STESAQDTYL DSQDHKSEVT 600
SQSGLSNSSD SLDSSTRPPS VTRGGVAPAP EAPEPPPKHA ALKSEQGTLT SSESHPEAAP 660
KRKLSSIGIQ VDCIQPVPKE EPSPATKFQS IGVQVEDDWR SSVPSHSMSS RRDTDSDTQD 720
ANDSSCKSSE RSLPDCTPHP NSISIDAGPR QAPKIAQIKR NLSYGDNSDP ALEASSLPPP 780
DPWLETSSSS PAEPAQPGAC RRDGYWFLKL LQAETERLEG WCCQMDKETK ENNLSEEVLG 840
KVLSAVGSAQ LLMSQKFQQF RGLCEQNLNP DANPRPTAQD LAGFWDLLQL SIEDISMKFD 900
ELYHLKANSW QLVETPEKRK EEKKPPPPVP KKPAKSKPAV SRDKASDASD KQRQEARKRL 960
LAAKRAASVR QNSATESADS IEIYVPEAQT RL 992

Gene Ontology

GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0045202; C:synapse; IEA:Compara.
GO:0007267; P:cell-cell signaling; IEA:InterPro.

Interpro

IPR005026; GKAP.

Pfam

PF03359; GKAP

SMART

PROSITE

PRINTS