CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040477
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase receptor 
Protein Synonyms/Alias
  
Gene Name
 Kit 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
604RNRLSFGKTLGAGAFubiquitination[1]
613LGAGAFGKVVEATAYubiquitination[1]
704RDSFIFSKQEEQAEAubiquitination[1]
936QVVQLIEKQISDSTKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 987 AA 
Protein Sequence
RERSSESSAA TAMRGARGAW DLLCVLLVLL RGQTATSQPS ASPGEPSPPS IHPAQSELIV 60
EAGDTLSLTC IDPDFVRWTF KTYFNEMVEN KKNEWIQEKA EATRTGTYTC SNSNGLTSSI 120
YVFVRDPAKL FLVGLPLFGK EDSDALVRCP LTDPQVSNYS LIECDGKSLP TDLTFVPNPK 180
AGITIKNVKR AYHRLCVRCA AQRDGTWLHS DKFTLKVRAA IKAIPVVSVP ETSHLLKKGD 240
TFTVVCTIKD VSTSVNSMWL KMNPQPQHIA QVKHNSWHRG DFNYERQETL TISSARVDDS 300
GVFMCYANNT FGSANVTTTL KVVEKGFINI SPVKNTTVFV TDGENVDLVV EYEAYPKPEH 360
QQWIYMNRTS ANKGKDYVKS DNKSNIRYVN QLRLTRLKGT EGGTYTFLVS NSDASASVTF 420
NVYVNTKPEI LTYDRLINGM LQCVAEGFPE PTIDWYFCTG AEQRCTTPVS PVDVQVQNVS 480
VSPFGKLVVQ SSIDSSVFRH NGTVECKASN DVGKSSAFFN FAFKEQIQAH TLFTPLLIGF 540
VVAAGAMGII VMVLTYKYLQ KPMYEVQWKV VEEINGNNYV YIDPTQLPYD HKWEFPRNRL 600
SFGKTLGAGA FGKVVEATAY GLIKSDAAMT VAVKMLKPSA HLTEREALMS ELKVLSYLGN 660
HMNIVNLLGA CTVGGPTLVI TEYCCYGDLL NFLRRKRDSF IFSKQEEQAE AALYKNLLHS 720
TEPSCDSSNE YMDMKPGVSY VVPTKTDKRR SARIDSYIER DVTPAIMEDD ELALDLDDLL 780
SFSYQVAKGM AFLASKNCIH RDLAARNILL THGRITKICD FGLARDIRND SNYVVKGNAR 840
LPVKWMAPES IFSCVYTFES DVWSYGIFLW ELFSLGSSPY PGMPVDSKFY KMIKEGFRMV 900
SPEHAPAEMY DVMKTCWDAD PLKRPTFKQV VQLIEKQISD STKHIYSNLA NCNPNPENPV 960
VVDHSVRVNS VGSSASSTQP LLVHEDA 987 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004716; F:receptor signaling protein tyrosine kinase activity; IEA:InterPro.
 GO:0005020; F:stem cell factor receptor activity; IDA:MGI.
 GO:0006935; P:chemotaxis; TAS:MGI.
 GO:0048066; P:developmental pigmentation; IMP:MGI.
 GO:0038093; P:Fc receptor signaling pathway; IEA:InterPro.
 GO:0035234; P:germ cell programmed cell death; IGI:MGI.
 GO:0006687; P:glycosphingolipid metabolic process; IMP:MGI.
 GO:0007243; P:intracellular protein kinase cascade; IDA:MGI.
 GO:0002320; P:lymphoid progenitor cell differentiation; IGI:MGI.
 GO:0002573; P:myeloid leukocyte differentiation; IMP:MGI.
 GO:0002318; P:myeloid progenitor cell differentiation; IGI:MGI.
 GO:0043069; P:negative regulation of programmed cell death; IMP:MGI.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IGI:MGI.
 GO:0010628; P:positive regulation of gene expression; IMP:MGI.
 GO:0043406; P:positive regulation of MAP kinase activity; IGI:MGI.
 GO:0046777; P:protein autophosphorylation; TAS:MGI.
 GO:0048070; P:regulation of developmental pigmentation; IMP:MGI.
 GO:0009314; P:response to radiation; IMP:MGI.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0007286; P:spermatid development; IMP:MGI. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR027263; SCGF_receptor.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
 IPR001824; Tyr_kinase_rcpt_3_CS. 
Pfam
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00240; RECEPTOR_TYR_KIN_III 
PRINTS