UniProt Accession

 TF3C5_HUMAN; Q9Y5Q8; A6NI44; A6NJB9; Q5T7U2; Q5T7U3; Q8N2U7; Q8N857; Q96GD9; Q9H4P2 

Genbank Protein ID

 AF133124; AY007123; AK055092; AK097295; AL162417; AL162417; CH471090; CH471090; BC009741; BC011355; BC017337; BC030157 

Genbank Nucleotide ID

 AAD41476.1; AAG01991.1; BAG51466.1; BAC04993.1; CAI13406.1; CAI13407.1; EAW88026.1; EAW88029.1; AAH09741.2; AAH11355.1; AAH17337.1; AAH30157.2 

Protein Name

 General transcription factor 3C polypeptide 5 

Protein Synonyms/Alias

 TF3C-epsilon; Transcription factor IIIC 63 kDa subunit; TFIIIC 63 kDa subunit; TFIIIC63; Transcription factor IIIC subunit epsilon 

Gene Name

 GTF3C5 

Gene Synonyms/Alias

 CDABP0017 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	GVVRDVAKMLPTLGG	ubiquitination	[1, 2]
58	RIYADPTKRLELYFR	ubiquitination	[2]
256	KVEEELRKLFDIRPI	ubiquitination	[1]
270	IWSRNAVKANISVHP	ubiquitination	[2]
339	APSDLPVKAKRSTYN	ubiquitination	[2, 3]
354	YSLPITVKKTSSQLV	ubiquitination	[2]
367	LVTMHDLKQGLGPSG	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 519 AA 

Protein Sequence

Gene Ontology

 GO:0000127; C:transcription factor TFIIIC complex; IDA:HGNC.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0042791; P:5S class rRNA transcription from RNA polymerase III type 1 promoter; IC:HGNC.
 GO:0042797; P:tRNA transcription from RNA polymerase III promoter; IC:HGNC. 

Interpro

 IPR019136; TF_IIIC_su-5. 

Pfam

 PF09734; Tau95 

SMART

  

PROSITE

  

PRINTS