UniProt Accession

 PSB7_MOUSE; P70195; O09084; Q542F7; Q9CZH4; Q9DCF7 

Genbank Protein ID

 D83585; Y10874; D85570; AK002823; AK012613; AK013961; AK075759; AK088276; AK088765; AK168823; BC057662 

Genbank Nucleotide ID

 BAA12017.1; CAA71824.1; BAA22857.1; BAB22385.1; BAB28354.1; BAB29085.1; BAC35937.1; BAC40251.1; BAC40556.1; BAE40650.1; AAH57662.1 

Protein Name

 Proteasome subunit beta type-7 

Protein Synonyms/Alias

 Macropain chain Z; Multicatalytic endopeptidase complex chain Z; Proteasome subunit Z 

Gene Name

 Psmb7 

Gene Synonyms/Alias

 Mmc14 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
72	EGMVVADKNCSKIHF	acetylation	[1]
72	EGMVVADKNCSKIHF	ubiquitination	[2]
195	DMEEEEAKKLVSEAI	ubiquitination	[2]
225	LCVISKSKLDFLRPF	ubiquitination	[2]
237	RPFSVPNKKGTRLGR	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity of the proteasome (By similarity). 

Sequence Annotation

 ACT_SITE 44 44 Nucleophile (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005839; C:proteasome core complex; IDA:UniProtKB.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0051603; P:proteolysis involved in cellular protein catabolic process; IEA:InterPro. 

Interpro

 IPR000243; Pept_T1A_subB.
 IPR024689; Proteasome_bsu_C.
 IPR016050; Proteasome_bsu_CS.
 IPR001353; Proteasome_sua/b.
 IPR023333; Proteasome_suB-type. 

Pfam

 PF12465; Pr_beta_C
 PF00227; Proteasome 

SMART

  

PROSITE

 PS00854; PROTEASOME_B_1
 PS51476; PROTEASOME_B_2 

PRINTS

 PR00141; PROTEASOME.