UniProt Accession

 Q5NCU0_MOUSE; Q5NCU0 

Genbank Protein ID

 AL596207 

Genbank Nucleotide ID

  

Protein Name

 Glycine receptor subunit alpha-1 

Protein Synonyms/Alias

  

Gene Name

 Glra1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
323	KSPEEMRKLFIQRAK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Cell junction; Cell membrane; Complete proteome; Ion channel; Ion transport; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 366 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0005622; C:intracellular; IDA:MGI.
 GO:0045211; C:postsynaptic membrane; IDA:MGI.
 GO:0016934; F:extracellular-glycine-gated chloride channel activity; IDA:MGI.
 GO:0016594; F:glycine binding; IDA:MGI.
 GO:0030977; F:taurine binding; IEA:Compara.
 GO:0022824; F:transmitter-gated ion channel activity; IEA:InterPro.
 GO:0007340; P:acrosome reaction; IMP:MGI.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0006936; P:muscle contraction; IEA:Compara.
 GO:0051970; P:negative regulation of transmission of nerve impulse; IEA:Compara.
 GO:0050884; P:neuromuscular process controlling posture; IMP:MGI.
 GO:0007218; P:neuropeptide signaling pathway; IEA:Compara.
 GO:2000344; P:positive regulation of acrosome reaction; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0001508; P:regulation of action potential; IMP:MGI.
 GO:0060080; P:regulation of inhibitory postsynaptic membrane potential; IMP:MGI.
 GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IMP:MGI.
 GO:0060013; P:righting reflex; IMP:MGI.
 GO:0001964; P:startle response; IMP:MGI.
 GO:0060012; P:synaptic transmission, glycinergic; IMP:MGI.
 GO:0007601; P:visual perception; IMP:MGI. 

Interpro

 IPR006028; GABAA_rcpt.
 IPR008127; Glycine_rcpt_A.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 

Pfam

 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 

SMART

  

PROSITE

 PS00236; NEUROTR_ION_CHANNEL 

PRINTS

 PR00253; GABAARECEPTR.
 PR01673; GLYRALPHA.
 PR00252; NRIONCHANNEL.