CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032107
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WD repeat-containing protein 81 
Protein Synonyms/Alias
 cDNA FLJ51331, highly similar to WD repeat protein 81 
Gene Name
 WDR81 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
75ELRQQDLKLDPAGRGubiquitination[1]
234GSDDNALKQELPRSVubiquitination[1, 2, 3]
283PGHSGAVKCVAPLSSubiquitination[1]
299DFFLSGSKDRTVRLWubiquitination[4]
537PPSQATTKLSSENFRubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 572 AA 
Protein Sequence
MGSLSSPTST CPTSATWFPS GAQARTILCV KTISLIALIC LRIGQEMVQQ HLSEPVATFF 60
QVFSQLHELR QQDLKLDPAG RGEGQLPQVV FSDGQQRPVD PALLDELQKV FTLEMAYTIY 120
VPFSCLLGDI IRKIIPNHEL VGELAALYLE SISPSSRNPA SVEPTMPGTG PEWDPHGGGC 180
PQDDGHSGTF GSVLVGNRIQ IPNDSRPENP GPLGPISGVG GGGLGSGSDD NALKQELPRS 240
VHGLSGNWLA YWQYEIGVSQ QDAHFHFHQI RLQSFPGHSG AVKCVAPLSS EDFFLSGSKD 300
RTVRLWPLYN YGDGTSETAP RLVYTQHRKS VFFVGQLEAP QHVVSCDGAV HVWDPFTGKT 360
LRTVEPLDSR VPLTAVAVMP APHTSITMAS SDSTLRFVDC RKPGLQHEFR LGGGLNPGLV 420
RALAISPSGR SVVAGFSSGF MVLLDTRTGL VLRGWPAHEG DILQIKAVEG SVLVSSSSDH 480
SLTVWKELEQ KPTHHYKSAS DPIHTFDLYG SEVVTGTVSN KIGVCSLLEP PSQATTKLSS 540
ENFRGTLTSL ALLPTKRHLL LGSDNGVIRL LA 572 
Gene Ontology
  
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS