CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016206
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Reticulon-4 receptor-like 1 
Protein Synonyms/Alias
 Nogo receptor-like 2; Nogo-66 receptor homolog 2; Nogo-66 receptor-related protein 3; NgR3 
Gene Name
 RTN4RL1 
Gene Synonyms/Alias
 NGRH2; NGRL2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
294LRHGQDLKLLRAEDFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May play a role in regulating axonal regeneration and plasticity in the adult central nervous system. 
Sequence Annotation
 DOMAIN 25 54 LRRNT.
 REPEAT 55 76 LRR 1.
 REPEAT 77 98 LRR 2.
 REPEAT 101 123 LRR 3.
 REPEAT 126 147 LRR 4.
 REPEAT 150 171 LRR 5.
 REPEAT 174 195 LRR 6.
 REPEAT 198 219 LRR 7.
 REPEAT 222 243 LRR 8.
 DOMAIN 255 306 LRRCT.
 LIPID 420 420 GPI-anchor amidated serine (Potential).  
Keyword
 Cell membrane; Complete proteome; Glycoprotein; GPI-anchor; Leucine-rich repeat; Lipoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 441 AA 
Protein Sequence
MLRKGCCVEL LLLLVAAELP LGGGCPRDCV CYPAPMTVSC QAHNFAAIPE GIPVDSERVF 60
LQNNRIGLLQ PGHFSPAMVT LWIYSNNITY IHPSTFEGFV HLEELDLGDN RQLRTLAPET 120
FQGLVKLHAL YLYKCGLSAL PAGVFGGLHS LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL 180
HGNKLWSLGP GTFRGLVNLD RLLLHENQLQ WVHHKAFHDL RRLTTLFLFN NSLSELQGEC 240
LAPLGALEFL RLNGNPWDCG CRARSLWEWL QRFRGSSSAV PCVSPGLRHG QDLKLLRAED 300
FRNCTGPASP HQIKSHTLTT TDRAARKEHH SPHGPTRSKG HPHGPRPGHR KPGKNCTNPR 360
NRNQISKAGA GKQAPELPDY APDYQHKFSF DIMPTARPKR KGKCARRTPI RAPSGVQQAS 420
SASSLGASLL AWTLGLAVTL R 441 
Gene Ontology
 GO:0046658; C:anchored to plasma membrane; IDA:UniProtKB.
 GO:0009986; C:cell surface; IDA:DFLAT.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0004872; F:receptor activity; IDA:UniProtKB.
 GO:0031103; P:axon regeneration; TAS:UniProtKB. 
Interpro
 IPR000483; Cys-rich_flank_reg_C.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 
Pfam
  
SMART
 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 
PROSITE
 PS51450; LRR 
PRINTS