CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037012
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mitochondrial-processing peptidase subunit beta 
Protein Synonyms/Alias
  
Gene Name
 PMPCB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39EQTVYYAKAFSKDLPubiquitination[1]
43YYAKAFSKDLPRAVEubiquitination[1, 2, 3]
114LGPTENIKSISRKDLubiquitination[1, 2, 3, 4]
119NIKSISRKDLVDYITubiquitination[5]
130DYITTHYKGPRIVLAubiquitination[1, 5]
351TIREVCTKYIYNRSPubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 403 AA 
Protein Sequence
MAFKGTKKRS QLDLELEIEN MGAHLNAYTS REQTVYYAKA FSKDLPRAVE ILADIIQNST 60
LGEAEIERER GVILREMQEV ETNLQEVVFD YLHATAYQNT ALGRTILGPT ENIKSISRKD 120
LVDYITTHYK GPRIVLAAAG GVSHDELLDL AKFHFGDSLC THKGEIPALP PCKFTGSEIR 180
VRDDKMPLAH LAIAVEAVGW AHPDTICLMV ANTLIGNWDR SFGGGMNLSS KLAQLTCHGN 240
LCHSFQSFNT SYTDTGLWGL YMVCESSTVA DMLHVVQKEW MRLCTSVTES EVARARNLLK 300
TNMLLQLDGS TPICEDIGRQ MLCYNRRIPI PELEARIDAV NAETIREVCT KYIYNRSPAI 360
AAVGYNHRSE LHEWKWNKLF SKRQTISYSY VNILLPQPQP QYV 403 
Gene Ontology
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR011249; Metalloenz_LuxS/M16.
 IPR011237; Pept_M16_dom.
 IPR011765; Pept_M16_N.
 IPR007863; Peptidase_M16_C. 
Pfam
 PF00675; Peptidase_M16
 PF05193; Peptidase_M16_C 
SMART
  
PROSITE
  
PRINTS