UniProt Accession

 PRS10_MOUSE; P62334; P49719; Q3TKK1; Q810A6; Q92524; Q9CXH9 

Genbank Protein ID

 AK012174; AK014354; AK144728; AK166961; BC043044; BC057997 

Genbank Nucleotide ID

 BAB28078.1; BAB29293.1; BAE26034.1; BAE39144.1; AAH43044.1; AAH57997.1 

Protein Name

 26S protease regulatory subunit 10B 

Protein Synonyms/Alias

 26S proteasome AAA-ATPase subunit RPT4; Proteasome 26S subunit ATPase 6; Proteasome subunit p42 

Gene Name

 Psmc6 

Gene Synonyms/Alias

 Sug2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MADPRDKALQDYRK	ubiquitination	[1]
20	RKKLLEHKEIDGRLK	ubiquitination	[1]
34	KELREQLKELTKQYE	ubiquitination	[1]
38	EQLKELTKQYEKSEN	ubiquitination	[1]
48	EKSENDLKALQSVGQ	ubiquitination	[1]
72	TEEKFIVKATNGPRY	acetylation	[2]
72	TEEKFIVKATNGPRY	ubiquitination	[1]
168	RVGIIPPKGCLLYGP	ubiquitination	[1]
180	YGPPGTGKTLLARAV	ubiquitination	[1]
197	QLDCNFLKVVSSSIV	ubiquitination	[1]
206	VSSSIVDKYIGESAR	acetylation	[2, 3, 4]
206	VSSSIVDKYIGESAR	ubiquitination	[1]
274	FDTLHRVKMIMATNR	ubiquitination	[1]
314	QARLDILKIHAGPIT	ubiquitination	[1]
369	VVQEDFMKAVRKVAD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. 

Sequence Annotation

 NP_BIND 174 181 ATP (Potential).
 MOD_RES 72 72 N6-acetyllysine (By similarity).
 MOD_RES 206 206 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 389 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0022624; C:proteasome accessory complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0030163; P:protein catabolic process; IEA:InterPro. 

Interpro

 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS