UniProt Accession

 TMED9_MOUSE; Q99KF1; Q9CX02 

Genbank Protein ID

 AK010259; BC004691 

Genbank Nucleotide ID

 BAB26802.2; AAH04691.1 

Protein Name

 Transmembrane emp24 domain-containing protein 9 

Protein Synonyms/Alias

 Glycoprotein 25L2; p24 family protein alpha-2; p24alpha2 

Gene Name

 Tmed9 

Gene Synonyms/Alias

 Gp25l2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
160	AEIAAKDKLSELQLR	acetylation	[1]
180	EQVEQIQKEQNYQRW	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity). 

Sequence Annotation

 DOMAIN 47 145 GOLD.
 REGION 121 160 Required for interaction with STX17 (By
 MOTIF 228 235 COPI vesicle coat-binding (Potential).
 MOTIF 228 229 COPII vesicle coat-binding (Potential).
 CARBOHYD 125 125 N-linked (GlcNAc...) (Potential).  

Keyword

 Coiled coil; Complete proteome; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Membrane; Protein transport; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 235 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048205; P:COPI coating of Golgi vesicle; ISS:UniProtKB.
 GO:0007030; P:Golgi organization; ISS:UniProtKB.
 GO:0010638; P:positive regulation of organelle organization; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR009038; GOLD. 

Pfam

 PF01105; EMP24_GP25L 

SMART

  

PROSITE

 PS50866; GOLD 

PRINTS