CPLM-002539

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-002539

UniProt Accession

ALF_DROME; P07764; A4V3F9; A5XCY2; P29841; Q24236; Q24237; Q7KRY9; Q8IMS1; Q8MQQ4; Q9VBG2; Q9VBG3

Genbank Protein ID

D10446; D10446; D10446; M98351; M98351; M98351; X60064; X60064; X60064; D10762; DQ864133; DQ864134; DQ864135; DQ864136; DQ864137; DQ864138; DQ864139; DQ864140; DQ864141; DQ864142; DQ864143; DQ864144; AE014297; AE014297; AE014297; AE014297; AE014297; AY058667; AY128452

Genbank Nucleotide ID

BAA01236.1; BAA01237.1; BAA01238.1; AAA99426.1; AAA99427.1; AAA99428.1; CAA42666.1; CAA42667.1; CAA42668.1; BAA01592.1; ABH06768.1; ABH06769.1; ABH06770.1; ABH06771.1; ABH06772.1; ABH06773.1; ABH06774.1; ABH06775.1; ABH06776.1; ABH06777.1; ABH06778.1; ABH06779.1; AAF56579.1; AAN14381.1; AAN14382.1; AAN14384.1; AAS65220.1; AAL13896.1; AAM75045.1

Protein Name

Fructose-bisphosphate aldolase

Protein Synonyms/Alias

Gene Name

Ald

Gene Synonyms/Alias

CG6058

Created Date

July 27, 2013

Organism

Drosophila melanogaster (Fruit fly)

NCBI Taxa ID

7227

Lysine Modification

Position	Peptide	Type	References
42	ESGPTMGKRLQDIGV	acetylation	[1]
230	YLEGTLLKPNMVTAG	acetylation	[1]

Reference

[1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702]

Functional Description

May take part in developmental stage-specific or tissue -specific sugar-phosphate metabolisms. Protein acts on two substrates fructose 1,6-bisphosphate and fructose 1-phosphate (like other class I aldolases).

Sequence Annotation

ACT_SITE 188 188 Proton acceptor (By similarity).
ACT_SITE 230 230 Schiff-base intermediate with
BINDING 56 56 Substrate.
BINDING 147 147 Substrate.
MOD_RES 2 2 N-acetylthreonine.

Keyword

3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Glycolysis; Lyase; Reference proteome; Schiff base.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

361 AA

Protein Sequence

MTTYFNYPSK ELQDELREIA QKIVAPGKGI LAADESGPTM GKRLQDIGVE NTEDNRRAYR 60
QLLFSTDPKL AENISGVILF HETLYQKADD GTPFAEILKK KGIILGIKVD KGVVPLFGSE 120
DEVTTQGLDD LAARCAQYKK DGCDFAKWRC VLKIGKNTPS YQSILENANV LARYASICQS 180
QRIVPIVEPE VLPDGDHDLD RAQKVTETVL AAVYKALSDH HVYLEGTLLK PNMVTAGQSA 240
KKNTPEEIAL ATVQALRRTV PAAVTGVTFL SGGQSEEEAT VNLSAINNVP LIRPWALTFS 300
YGRALQASVL RAWAGKKENI AAGQNELLKR AKANGDAAQG KYVAGSAGAG SGSLFVANHA 360
Y 361

Gene Ontology

GO:0031430; C:M band; IDA:FlyBase.
GO:0030018; C:Z disc; IDA:FlyBase.
GO:0004332; F:fructose-bisphosphate aldolase activity; IDA:FlyBase.
GO:0006096; P:glycolysis; IDA:FlyBase.
GO:0007498; P:mesoderm development; NAS:FlyBase.
GO:0007095; P:mitotic G2 DNA damage checkpoint; IGI:FlyBase.

Interpro

IPR000741; Aldolase_I.
IPR013785; Aldolase_TIM.

Pfam

PF00274; Glycolytic

SMART

PROSITE

PS00158; ALDOLASE_CLASS_I

PRINTS