UniProt Accession

 MEX3A_HUMAN; A1L020 

Genbank Protein ID

 AY950677 

Genbank Nucleotide ID

 AAY34145.1 

Protein Name

 RNA-binding protein MEX3A 

Protein Synonyms/Alias

 RING finger and KH domain-containing protein 4 

Gene Name

 MEX3A 

Gene Synonyms/Alias

 RKHD4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	GCFGGSAKDRGLLED	ubiquitination	[1, 2]
114	PKGASDAKLCALYKE	ubiquitination	[1]
127	KEAELRLKGSSNTTE	ubiquitination	[1, 2]
161	KIKALRAKTNTYIKT	ubiquitination	[1]
209	MIRASRNKSGAAFGV	ubiquitination	[1, 2]
242	VGLVVGPKGATIKRI	ubiquitination	[1]
247	GPKGATIKRIQQQTN	ubiquitination	[1]
294	HIAVRTGKILEYNNE	ubiquitination	[3]
329	RVHQPGCKPLSTFRQ	ubiquitination	[1]
454	EPLQGFSKLGGGGLR	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 RNA binding protein, may be involved in post- transcriptional regulatory mechanisms. 

Sequence Annotation

 DOMAIN 132 193 KH 1.
 DOMAIN 223 284 KH 2.
 ZN_FING 469 509 RING-type.  

Keyword

 Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 520 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 

Interpro

 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF00013; KH_1 

SMART

 SM00322; KH
 SM00184; RING 

PROSITE

 PS50084; KH_TYPE_1
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 

PRINTS