UniProt Accession

 UVRY_ECOLI; P0AED5; P07027 

Genbank Protein ID

 M24615; U00096; AP009048; X05398; X03691 

Genbank Nucleotide ID

 AAA24755.1; AAC74981.1; BAA15734.1; CAA28982.1; CAA27328.1 

Protein Name

 Response regulator UvrY 

Protein Synonyms/Alias

  

Gene Name

 uvrY 

Gene Synonyms/Alias

 yecB; b1914; JW1899 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
25	RRILEDIKGIKVVGE	acetylation	[1]
41	SCGEDAVKWCRTNAV	acetylation	[1]
142	LSQIEPEKTESPFAS	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms. 

Sequence Annotation

 DOMAIN 1 119 Response regulatory.
 DOMAIN 143 208 HTH luxR-type.
 DNA_BIND 167 186 H-T-H motif (By similarity).
 MOD_RES 54 54 4-aspartylphosphate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000156; F:phosphorelay response regulator activity; IDA:EcoCyc.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR001789; Sig_transdc_resp-reg_receiver.
 IPR000792; Tscrpt_reg_LuxR_C.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00196; GerE
 PF00072; Response_reg 

SMART

 SM00421; HTH_LUXR
 SM00448; REC 

PROSITE

 PS00622; HTH_LUXR_1
 PS50043; HTH_LUXR_2
 PS50110; RESPONSE_REGULATORY 

PRINTS

 PR00038; HTHLUXR.