| Tag | Content |
|---|
| CPLM ID | CPLM-023617 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cofilin-2 |
Protein Synonyms/Alias | Cofilin, muscle isoform |
Gene Name | CFL2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 13 | TVNDEVIKVFNDMKV | ubiquitination | [1] | | 144 | VNGLDDIKDRSTLGE | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity). |
Sequence Annotation | DOMAIN 4 153 ADF-H.
MOTIF 30 34 Nuclear localization signal (Potential).
MOD_RES 2 2 N-acetylalanine.
MOD_RES 3 3 Phosphoserine.
MOD_RES 6 6 Phosphothreonine (By similarity).
MOD_RES 89 89 Phosphotyrosine (By similarity). |
Keyword | Acetylation; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Nemaline myopathy; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 166 AA |
Protein Sequence | MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE EAKQILVGDI 60
GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS 120
KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKLGGNVVVS LEGKPL 166 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; IEA:InterPro. GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell. GO:0030042; P:actin filament depolymerization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |