CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011445
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U3 small nucleolar RNA-associated protein 4 
Protein Synonyms/Alias
 U3 snoRNA-associated protein 4; U three protein 4; U3 protein 4 required for transcription; t-UTP4 
Gene Name
 UTP4 
Gene Synonyms/Alias
 YDR324C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
464GNKLKVTKLDNDLLLacetylation[1]
773QKAFIQPKLVF****acetylation[2]
Reference
 [1] Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures.
 Xie H, Bandhakavi S, Roe MR, Griffin TJ.
 J Proteome Res. 2007 May;6(5):2019-26. [PMID: 17397211]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t-UTPs). 
Sequence Annotation
 REPEAT 35 40 WD 1.
 REPEAT 132 169 WD 2.
 REPEAT 178 214 WD 3.
 REPEAT 230 266 WD 4.
 REPEAT 271 308 WD 5.
 REPEAT 417 452 WD 6.  
Keyword
 Complete proteome; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; Ribosome biogenesis; rRNA processing; Transcription; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 776 AA 
Protein Sequence
MSSSLLSVLK EKSRSLKIRN KPVKMTSQER MIVHRCRFVD FTPATITSLA FSHKSNINKL 60
TPSDLRLAIG RSNGNIEIWN PRNNWFQEMV IEGGKDRSIE GLCWSNVNGE SLRLFSIGGS 120
TVVTEWDLAT GLPLRNYDCN SGVIWSISIN DSQDKLSVGC DNGTVVLIDI SGGPGVLEHD 180
TILMRQEARV LTLAWKKDDF VIGGCSDGRI RIWSAQKNDE NMGRLLHTMK VDKAKKESTL 240
VWSVIYLPRT DQIASGDSTG SIKFWDFQFA TLNQSFKAHD ADVLCLTTDT DNNYVFSAGV 300
DRKIFQFSQN TNKSQKNNRW VNSSNRLLHG NDIRAICAYQ SKGADFLVSG GVEKTLVINS 360
LTSFSNGNYR KMPTVEPYSK NVLVNKEQRL VVSWSESTVK IWTMGTDSST EQNYKLVCKL 420
TLKDDQNIST CSLSPDGQVL VVGRPSTTKV FHLQPVGNKL KVTKLDNDLL LRTSTKLVKF 480
IDNSKIVICS CEDDVFIVDL ESEEDEKPQE VELLEVTSTK SSIKVPYINR INHLEVDQNI 540
AVISRGCGVV DILDLKARIS KPLARLNNFI TAVHINTSRK SVVVITADNK IYEFNMNLNS 600
EAENEDSESV LTQWSKNNTD NLPKEWKTLK ENCVGIFSDI ENSSRLWFWG ATWISRIDFD 660
VDFPINKRRK QKKRTHEGLT ITDESNFMND EEDDEDDDID MEISENLNVL LNQGNKIKST 720
DVQRNEESSG HFFFTDKYKP LLFVDLISSN ELAIIERNPL TFHSKQKAFI QPKLVF 776 
Gene Ontology
 GO:0032040; C:small-subunit processome; IDA:SGD.
 GO:0034455; C:t-UTP complex; IDA:SGD.
 GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.
 GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS