CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015895
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 551 
Protein Synonyms/Alias
 Zinc finger protein KOX23 
Gene Name
 ZNF551 
Gene Synonyms/Alias
 KOX23 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
100KGNTPTQKTHLSEIKubiquitination[1]
107KTHLSEIKMCVPVLKubiquitination[1]
130QTTSPVQKSYLGSTSubiquitination[2]
161YNEEEPWKRKVDEATubiquitination[1]
163EEEPWKRKVDEATFVubiquitination[1]
291CEESFSKKCHLILHKubiquitination[1]
347CRKTFSYKSNLIEHQubiquitination[1, 2]
370YECGECGKSFRQSSSubiquitination[1]
431CGKSFSCKSELIQHQubiquitination[1]
487CEKSFSRKFILIQHQubiquitination[1]
510YECSECGKSFTRKSDubiquitination[1]
594YECSECGKSFSQSSSubiquitination[1]
650YECSECGKSFSRKSNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 29 100 KRAB.
 ZN_FING 251 273 C2H2-type 1.
 ZN_FING 279 301 C2H2-type 2.
 ZN_FING 335 357 C2H2-type 3.
 ZN_FING 363 385 C2H2-type 4.
 ZN_FING 391 413 C2H2-type 5.
 ZN_FING 419 441 C2H2-type 6.
 ZN_FING 447 469 C2H2-type 7.
 ZN_FING 475 497 C2H2-type 8.
 ZN_FING 503 525 C2H2-type 9.
 ZN_FING 531 553 C2H2-type 10.
 ZN_FING 559 581 C2H2-type 11.
 ZN_FING 587 609 C2H2-type 12.
 ZN_FING 615 637 C2H2-type 13.
 ZN_FING 643 665 C2H2-type 14.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 670 AA 
Protein Sequence
MPAPVGRRSP PSPRSSMAAV ALRDSAQGMT FEDVAIYFSQ EEWELLDESQ RFLYCDVMLE 60
NFAHVTSLGY CHGMENEAIA SEQSVSIQVR TSKGNTPTQK THLSEIKMCV PVLKDILPAA 120
EHQTTSPVQK SYLGSTSMRG FCFSADLHQH QKHYNEEEPW KRKVDEATFV TGCRFHVLNY 180
FTCGEAFPAP TDLLQHEATP SGEEPHSSSS KHIQAFFNAK SYYKWGEYRK ASSHKHTLVQ 240
HQSVCSEGGL YECSKCEKAF TCKNTLVQHQ QIHTGQKMFE CSECEESFSK KCHLILHKII 300
HTGERPYECS DREKAFIHKS EFIHHQRRHT GGVRHECGEC RKTFSYKSNL IEHQRVHTGE 360
RPYECGECGK SFRQSSSLFR HQRVHSGERP YQCCECGKSF RQIFNLIRHR RVHTGEMPYQ 420
CSDCGKSFSC KSELIQHQRI HSGERPYECR ECGKSFRQFS NLIRHRSIHT GDRPYECSEC 480
EKSFSRKFIL IQHQRVHTGE RPYECSECGK SFTRKSDLIQ HRRIHTGTRP YECSECGKSF 540
RQRSGLIQHR RLHTGERPYE CSECGKSFSQ SASLIQHQRV HTGERPYECS ECGKSFSQSS 600
SLIQHQRGHT GERPYECSQC GKPFTHKSDL IQHQRVHTGE RPYECSECGK SFSRKSNLIR 660
HRRVHTEERP 670 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS