UniProt Accession

 SIC1_YEAST; P38634; D6VY79 

Genbank Protein ID

 U01300; X78309; Z73251; U53880; BK006945 

Genbank Nucleotide ID

 AAA20052.1; CAA55118.1; CAA97638.1; AAB67583.1; DAA09395.1 

Protein Name

 Protein SIC1 

Protein Synonyms/Alias

 CDK inhibitor p40 

Gene Name

 SIC1 

Gene Synonyms/Alias

 SDB25; YLR079W; L9449.8 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
253	DVITYVNKKGEVVEK	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Substrate and inhibitor of the cyclin-dependent protein kinase CDC28. Its activity could be important for faithful segregation of chromosomes to daughter cells. It acts in response to a signal from a post-start checkpoint. 

Sequence Annotation

 MOD_RES 5 5 Phosphothreonine; by PHO85.
 MOD_RES 33 33 Phosphothreonine.
 MOD_RES 76 76 Phosphoserine.
 MOD_RES 173 173 Phosphothreonine.
 MOD_RES 198 198 Phosphoserine.
 MOD_RES 201 201 Phosphoserine.
 MOD_RES 268 268 Lysine derivative.
 MOD_RES 272 272 Lysine derivative.
 MOD_RES 274 274 Lysine derivative.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IDA:SGD.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IGI:SGD.
 GO:0016242; P:negative regulation of macroautophagy; IMP:SGD.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IMP:SGD. 

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