CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035417
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein LOC100360342 
Protein Synonyms/Alias
  
Gene Name
 Msh6 
Gene Synonyms/Alias
 LOC100360342 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
144PTRGWVSKRMLKPYTacetylation[1]
168GGHFYSSKSEILRAMacetylation[1]
848YEETTYSKKKIIDFLubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1357 AA 
Protein Sequence
MSRQSTLYSF FPKSPALGDT KEAAARASRK GAAASGASAS RGRDAAWSEA GPGSRPAALS 60
TSLPEAKDLN GGLRRSAAPA VPASSSCDFS PGDLVWAKME GYPWWPCLVY NHPFDGTFIR 120
KNGKSARVHV QFFDDSPTRG WVSKRMLKPY TGSKSKEAQK GGHFYSSKSE ILRAMQRADE 180
ALSKDKAQRL ELAVCDEPSE PEEEEEEEVH GAYLSDKSEE ENQDESEEET QPNAQGPRRS 240
SRQVKKRRVI SDSESDIGGS DVEFKPDSKQ EGSSDEVSSG VGDSDSEGLG SFGKGAPKRK 300
RTVAAHGGLK RKSLKKETGS AKQATRILSE TKSTLSAFCA PQNSESQTHV CGGGNDSSGP 360
TIWYHETLEW LKPEKRRDEN RRRPDHPDYN SSTLYVPEDF LNSCTPGMRR WWQFKSQNFD 420
LVIFYKVGKF YELYHMDAVI GVSELGLIFM KGNWAHSGFP EIAFGRFSDS LVQKGYKVAR 480
VEQTETPEMM EARCRKMAHV SKFDRVVRRE ICRIITKGTQ TYSVLDGDPS ENYSRYLLSL 540
KEKEEDSSGH MRAYGVCFVD TSLGKFFLGQ FSDDRHCSRL RTLVAHYPPV QILFEKGNLS 600
TETKTVLKGY WSSCLQEGLI PGSQFWDATK TLRTLLEGGY FTGNEGSGAE LPPVLKAMTS 660
ESDSVGLTPG EESELSLSAL GGCVFYLKKC LIDQELLSMA NFEEYFPLDS DMVGTVKPGA 720
VFTKASQRMV LDAVTLSNLE IFLNGTNGST EGTLLERLDT CHTPFGKRLL KQWLCAPLCS 780
PSAISDRLDA IEDLMAVPDK VAEVADLLKK LPDLERLLSK IHNVGSPLKS QNHPDTRAIM 840
YEETTYSKKK IIDFLSALEG FKVMCKITRL MEDVADGFKS KTLKQVVTLQ TKSPKGRFPD 900
LTAELNRWDT AFDHEKARKT GLITPKAGFD SDYDQALADI RENEQSLLEY LDKQRSRIGC 960
RNIVYWGIGR NRYQLEIPEN FATRNLPEEY ELKSTKKGCK RYWTKVIEKK LSNLINAEER 1020
RDASLKDCMR RLFYNFDKNH KDWQSAVECT AVLDVLLCLA SYSQGGDGPM CRPVLLLPGE 1080
DTHPFLELKG SRHPCITKTF FGDDFIPNDI LIGCEEDAEA DGKAYCVLVT GPNMGGKSTL 1140
IRQAGLLAVM AQMGCYVPAE LCRLTPVDRV FTRLGASDRI MSGESTFFVE LSETASILRH 1200
ATAHSLVLVD ELGRGTATFD GTAIASAVVK ELAETIKCRT LFSTHYHSLV EDYSKNVCVR 1260
LGHMACMVEN ECEDPSQETI TFLYKFIKGA CPKSYGFNAA RLANLPEEVI QKGHRKAREF 1320
ERMNQALQLF REVCLASERP TVNSEAIHRL LALVNQL 1357 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0030983; F:mismatched DNA binding; IEA:InterPro.
 GO:0006298; P:mismatch repair; IEA:InterPro. 
Interpro
 IPR017261; DNA_mismatch_repair_Msh6.
 IPR015536; DNA_mismatch_repair_MSH6_C.
 IPR007695; DNA_mismatch_repair_MutS-lik_N.
 IPR000432; DNA_mismatch_repair_MutS_C.
 IPR007861; DNA_mismatch_repair_MutS_clamp.
 IPR007696; DNA_mismatch_repair_MutS_core.
 IPR016151; DNA_mismatch_repair_MutS_N.
 IPR007860; DNA_mmatch_repair_MutS_con_dom.
 IPR027417; P-loop_NTPase.
 IPR000313; PWWP. 
Pfam
 PF01624; MutS_I
 PF05188; MutS_II
 PF05192; MutS_III
 PF05190; MutS_IV
 PF00488; MutS_V
 PF00855; PWWP 
SMART
 SM00534; MUTSac
 SM00533; MUTSd
 SM00293; PWWP 
PROSITE
 PS00486; DNA_MISMATCH_REPAIR_2
 PS50812; PWWP 
PRINTS