CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039408
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sodium channel protein type 2 subunit alpha 
Protein Synonyms/Alias
  
Gene Name
 Scn2a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
458QMLEQLKKQQEEAQAubiquitination[1]
1021QKGIDFVKRKIREFIubiquitination[1]
1037KAFVRKQKALDEIKPubiquitination[1]
1043QKALDEIKPLEDLNNubiquitination[1]
1072GKDLNYLKDGNGTTSubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1706 AA 
Protein Sequence
MARSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK 60
SLPFIYGDIP PEMVSEPLED LDPYYINKKT FIVLNKGKAI SRFSATSALY ILTPFNPIRK 120
LAIKILVHSY PFDSYSLVML VLVNFVFMTI YNNPPDWTKN VEYTFTGIYT FESLIKILAR 180
GFCLEDFTFL RDPWNWLDFT VITFAYVTEF VNLGNVSALR TFRVLRALKT ISVIPGLKTI 240
VGALIQSVKK LSDVMILTVF CLSVFALIGL QLFMGNLRNK CLQWPPDNST FEINITSFFN 300
NSLDWNGTAF NRTVNMFNWD EYIEDKSHFY FLEGQNDALL CGNSSDAGQC PEGYICVKAG 360
RNPNYGYTSF DTFSWAFLSL FRLMTQDFWE NLYQLTLRAA GKTYMIFFVL VIFLGSFYLI 420
NLILAVVAMA YEEQNQATLE EAEQKEAEFQ QMLEQLKKQQ EEAQAAAAAA SAESRDFSGA 480
GGIGVFSESS SVASKLSSKS EKELKNRRKK KKQKEQAGEE EKEDAVRKSA SEDSIRKKGF 540
RFSLEGSRLT YEKRFSSPHQ SLLSIRGSLF SPRRNSRASL FSFKGRVKDI GSENDFADDE 600
HSTFEDNDSR RDSLFVPHRH GERRPSNVSQ ASRASRGIPT LPMNGKMHSA VDCNGVVSLV 660
GGPSALTSPV GQLLPEGTTT ETEIRKRRSS SYHVSMDLLE DPSRQRAMSM ASILTNTMEE 720
LEESRQKCPP CWYKFANMCL IWDCCKPWLK VKHVVNLVVM DPFVDLAITI CIVLNTLFMA 780
MEHYPMTEQF SSVLSVGNLV FTGIFTAEMF LKIIAMDPYY YFQEGWNIFD GFIVSLSLME 840
LGLANVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS VGALGNLTLV LAIIVFIFAV 900
VGMQLFGKSY KECVCKISND CELPRWHMHD FFHSFLIVFR VLCGEWIETM WDCMEVAGQT 960
MCLTVFMMVM VIGNLVVLNL FLALLLSSFS SDNLAATDDD NEMNNLQIAV GRMQKGIDFV 1020
KRKIREFIQK AFVRKQKALD EIKPLEDLNN KKDSCISNHT TIEIGKDLNY LKDGNGTTSG 1080
IGSSVEKYVV DESDYMSFIN NPSLTVTVPI ALGESDFENL NTEEFSSESD MEESKEKLNA 1140
TSSSEGSTVD IGAPAEGEQP EAEPEESLEP EACFTEDCVR KFKCCQISIE EGKGKLWWNL 1200
RKTCYKIVEH NWFETFIVFM ILLSSGALAF EDIYIEQRKT IKTMLEYADK VFTYIFILEM 1260
LLKWVAYGFQ MYFTNAWCWL DFLIVDVSLV SLTANALGYS ELGAIKSLRT LRALRPLRAL 1320
SRFEGMRVVV NALLGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYHCI NYTTGEMFDV 1380
SVVNNYSECQ ALIESNQTAR WKNVKVNFDN VGLGYLSLLQ VATFKGWMDI MYAAVDSRNV 1440
ELQPKYEDNL YMYLYFVIFI IFGSFFTLNL FIGVIIDNFN QQKKKMSQDI FMTEEQKKYY 1500
NAMKKLGSKK PQKPIPRPAN KFQGMVFDFV TKQVFDISIM ILICLNMVTM MVETDDQSQE 1560
MTNILYWINL VFIVLFTGEC VLKLISLRHY YFTIGWNIFD FVVVILSIVG MFLAELIEKY 1620
FVSPTLFRVI RLARIGRILR LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG 1680
MSNFAYVKRE VGIDDMFNFE TFGNSM 1706 
Gene Ontology
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0033270; C:paranode region of axon; IEA:Compara.
 GO:0030315; C:T-tubule; IEA:Compara.
 GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
 GO:0005248; F:voltage-gated sodium channel activity; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0007399; P:nervous system development; IEA:Compara.
 GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. 
Interpro
 IPR024583; DUF3451.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR010526; Na_trans_assoc. 
Pfam
 PF11933; DUF3451
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
  
PROSITE
  
PRINTS