CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010594
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial 
Protein Synonyms/Alias
 DmPDK; Pyruvate dehydrogenase kinase 
Gene Name
 Pdk 
Gene Synonyms/Alias
 CG8808 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
49GQNACEKKSYIFLRKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. 
Sequence Annotation
 DOMAIN 137 369 Histidine kinase.
 NP_BIND 253 260 ATP (By similarity).
 NP_BIND 313 314 ATP (By similarity).
 NP_BIND 330 335 ATP (By similarity).
 BINDING 294 294 ATP (By similarity).  
Keyword
 ATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 413 AA 
Protein Sequence
MRLFPVRFSA ASSSMASLAK MLDFYSGFNP SPLSIKQFMD FGQNACEKKS YIFLRKELPV 60
RLANIMKEIA LLPDNLLHTR SVSEVSSWYV KSFEDVLVYE KAEPTHDNLQ KFVADLDLIR 120
NRHNDVVQTM AQGVIEMKEN EGGQVDAPTE SSIQYFLDRL YMSRISIRML INQHTLLFGG 180
NPHAGGRHIG CLDPACDLSD VVRDAYENAR FLCDQYYLTS PALEIQQHSS EPGDNLPIRT 240
VYVPSHLYYM LFELFKNSMR AVVEHHGHDN NDTLPPLKVA ICKGKEDICV KISDQGGGIP 300
RSQTDQLFKY MYSTAPQPSK SDLHTVPLAG YGYGLPISRL YARYFHGDIV LLSCEGFGTD 360
AIIYLKALSD EANELLPIFN KTSSKFYRAT VPTGDWSNQV KYAKKKKTSA VNQ 413 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity; IEA:EC.
 GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW. 
Interpro
 IPR018955; BCDHK/PDK_N.
 IPR003594; HATPase_ATP-bd.
 IPR005467; Sig_transdc_His_kinase_core. 
Pfam
 PF10436; BCDHK_Adom3
 PF02518; HATPase_c 
SMART
 SM00387; HATPase_c 
PROSITE
 PS50109; HIS_KIN 
PRINTS